Renal: Renal Regulation of Acid-Base Balance Flashcards Preview

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Flashcards in Renal: Renal Regulation of Acid-Base Balance Deck (23):
1

Acids and bases are subject to the same constraints of input and output balance as other substances.

There are multiple routes for the entry of acids or bases

Balance Principle

2

How do Acids and Bases enter?

1. Metabolism
2. Activity of the GI tract adding acids or bases
3. Processing ingested food
4. Metabolism of stored fat and glycogen
5. Kidneys

3

What is a Buffer?

Prevents large changes in pH
Maintain normal range
Doesn't have an infinite capacity

4

What is the ECF's buffer?

C02-bicarbonate system.
( CO2 + H2O H2CO3 HCO3- +H )

ECF is the 1st line of defense of ingested acids

5

Carbonic Acid is what formula?

H2CO3

6

What are the ICF's buffers?

Protein
Phosphate
K+/H+ Exchanger.

7

True/False:
More buffering in the body is done by the ICF.

True. Because ICF has more fluid there are LOT more buffers in the ICF

8

What's the normal pH range?

7.35-7.45

9

Explain events of Acidosis

Too much acids outside the cell; causes K+ to move out and H+ to move in.
The H+ ion is buffered inside the cell

10

The concentration of CO2 is essentially constant. Is CO2 an acid or base?

Acid

11

CO2 changes impact pH (short-term). What's one of the long-term effects of CO2 changes?

Impact on Kidney's function of Bicarbonate.

12

True/False: Changes in H+ content changes BICARBONATE levels, NOT CO2.

True

13

What are the characteristics of Bicarbonate?

Freely Filtered
Plasma concentration of 24mmol/L
Normal GFR is 180L/day

14

What's the Filtered Load of Bicarbonate?

Plasma Concentration - 24mmol/L
Normal GFR - 180L/day

GFR x Px = 4320mmol/day

15

True/False:

About 100% of Bicarbonate is reabsorbed

True.

Bicarbonate is 100% reabsorbed regardless of too much acid/base in body.

16

Is Ammonium (NH4+) an acid or base?

Acid

17

What happens to Bicarbonate at the Proximal Tubule of the Kidney?

Reabsorbed

18

What happens to Bicarbonate at the Distal Tubule of the Kidney?

Secrete either protons or bicarbonate to balance the net input

19

Is Bicarbonate (HCO3-) an acid or base?

Base

20

Too much Bicarb then,

secrete Bicarbonate

21

Too much Acid then,

secrete Acid

22

The ONLY antiporter in the Proximal Tubule is?

Na+/H+ exchanger

23

True/False:

The Na+/H+ exchanger is increased by Angiotensin II

True