Flashcards in Reoviridae Deck (16):
What are the major characteristics of the reoviridae family? (ds/ss, RNA/DNA, pos/neg, env/non-env)
non-enveloped, icosahedral dsRNA
If a virus is un-enveloped, does that make it more or less stable?
more stable, heat and pH resistant
What are the four genera in the reoviridae family?
How is rotavirus transmitted?
What is the structure of reoviridae virus genomes?
dsRNA, segmented into 10-12 segments
What is the course of rotavirus infection in the human body?
- infects villi of small intestine and causes blunting and diarrhea
- the NSP4 protein of rotavirus has a toxin-like activity to promote secretory diarrhea
- enterocytes are replaced by crypt cells with different Na/K channels
How do we diagnose rotavirus?
- measuring the viral antigen in the stool by enzyme immune assay and latex agglutination
- RT-PCR to distinguish the genotype
- serologic assays are not sensitive
What is rotavirus? What does it cause in patients?
a member of reoviridae
Causes diarrhea, especially in children
highly, highly contagious
How do we treat rotavirus?
supportive care, hydration and electrolytes
How do we prevent rotavirus?
2 live oral vaccines are available: RotaTeq and RotaRix
What are coltiviruses?
the colorado tick fever virus
How are coltiviruses transmitted?
from rodents to humans through a tick (dermacentor)
What are some clinical symptoms of coltivirus?
- flu-like symptoms
- rash, conjunctivitis
- abdominal pain and diarrhea
How do we diagnose coltivirus?
viral antigen or RNA
How do we treat coltivirus?
fluids and anti-pyretics
AKA supportive care