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Flashcards in reproductive Deck (65)
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1

leuprolide MOA

gnRh agnoist

2

ethiny estradiol MOA

Er agonist

3

DES MOA

ER agnoist

4

mestranol MOA

ER agonist

5

clomiphene MOA

anatg of ER at the hypothalamus

6

tamoxifen MOA

antag at breast
ag at bone
ag at endometrium

7

raloxifene MOA

antag at breast
ag at bone
antag at endometrium

8

anastrozole MOA

aromatase inhibitor

9

exemestane MOA

aromatase inhibitor

10

progestin MOA

progestoerone receptor agonist

11

mifepristone Ru-486 MOA

competitive inhibitor of progestins at the PR

12

terbutaline MOA

b2 agonist

13

ritodrine MOA

b2 agonist

14

danazol MOA

synthetic androgen that acts as partial agonist at androgen receptors

15

testosterone MOA

agonist at AR

16

methyltestosterone MOA

agonist at AR

17

finasteride MOA

inhibits 5 alpha reductase

18

flutamide MOA

nonsteroidal competitive inhibitor at AR

19

ketoconazole MOA

inhibites seroid syntheisis @ 17, 20 desmolase

20

spironolactone MOA

inhibites steroid binding, 17 alpha hydroxylase, 17,20 desmolase

21

tamsulosin MOA

alpha 1 antqagonist

22

sidenafil/vardenafil/tadalafil MOA

inhibit PDE5

23

minoxidil MOA

direct arteriolar vasodilator

24

uses of leuprolide

moa = GnRH agonist
pulsatile: infertility
contiuous: prostate cancer after flutamide blocks ar
continous: uterine fibroids
continuous: precocious puberty

25

usese of ethinyl estradiol, DES and mestranol

ER agonists
hypogonadism or ovarina gailure
menstural abrnoamlities, HRT in post menopa
men with androgen dependent prostate cancer

26

use of clomiphene

inhibits ER at the hypothalamus
PCOS infertility treatmetn vrs anovulation

27

use of tamoxifen

antag at breast
ag at bone
ag at endo
to treat and prevent ER/PR positive breast cancer

28

use of raloxifen

antag at breast
ag at bone
antag at end
osteoporosis

29

use of HRT

prevent and reliefe menopausal symptoms
osteoporosis

30

use of anastrozole

aromatse inhibitors
postmenopausal women wit ER positive breast cancer