Flashcards in reproductive Deck (65)
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1
leuprolide MOA
gnRh agnoist
2
ethiny estradiol MOA
Er agonist
3
DES MOA
ER agnoist
4
mestranol MOA
ER agonist
5
clomiphene MOA
anatg of ER at the hypothalamus
6
tamoxifen MOA
antag at breast
ag at bone
ag at endometrium
7
raloxifene MOA
antag at breast
ag at bone
antag at endometrium
8
anastrozole MOA
aromatase inhibitor
9
exemestane MOA
aromatase inhibitor
10
progestin MOA
progestoerone receptor agonist
11
mifepristone Ru-486 MOA
competitive inhibitor of progestins at the PR
12
terbutaline MOA
b2 agonist
13
ritodrine MOA
b2 agonist
14
danazol MOA
synthetic androgen that acts as partial agonist at androgen receptors
15
testosterone MOA
agonist at AR
16
methyltestosterone MOA
agonist at AR
17
finasteride MOA
inhibits 5 alpha reductase
18
flutamide MOA
nonsteroidal competitive inhibitor at AR
19
ketoconazole MOA
inhibites seroid syntheisis @ 17, 20 desmolase
20
spironolactone MOA
inhibites steroid binding, 17 alpha hydroxylase, 17,20 desmolase
21
tamsulosin MOA
alpha 1 antqagonist
22
sidenafil/vardenafil/tadalafil MOA
inhibit PDE5
23
minoxidil MOA
direct arteriolar vasodilator
24
uses of leuprolide
moa = GnRH agonist
pulsatile: infertility
contiuous: prostate cancer after flutamide blocks ar
continous: uterine fibroids
continuous: precocious puberty
25
usese of ethinyl estradiol, DES and mestranol
ER agonists
hypogonadism or ovarina gailure
menstural abrnoamlities, HRT in post menopa
men with androgen dependent prostate cancer
26
use of clomiphene
inhibits ER at the hypothalamus
PCOS infertility treatmetn vrs anovulation
27
use of tamoxifen
antag at breast
ag at bone
ag at endo
to treat and prevent ER/PR positive breast cancer
28
use of raloxifen
antag at breast
ag at bone
antag at end
osteoporosis
29
use of HRT
prevent and reliefe menopausal symptoms
osteoporosis
30
