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Flashcards in reproductive Deck (65):
1

leuprolide MOA

gnRh agnoist

2

ethiny estradiol MOA

Er agonist

3

DES MOA

ER agnoist

4

mestranol MOA

ER agonist

5

clomiphene MOA

anatg of ER at the hypothalamus

6

tamoxifen MOA

antag at breast
ag at bone
ag at endometrium

7

raloxifene MOA

antag at breast
ag at bone
antag at endometrium

8

anastrozole MOA

aromatase inhibitor

9

exemestane MOA

aromatase inhibitor

10

progestin MOA

progestoerone receptor agonist

11

mifepristone Ru-486 MOA

competitive inhibitor of progestins at the PR

12

terbutaline MOA

b2 agonist

13

ritodrine MOA

b2 agonist

14

danazol MOA

synthetic androgen that acts as partial agonist at androgen receptors

15

testosterone MOA

agonist at AR

16

methyltestosterone MOA

agonist at AR

17

finasteride MOA

inhibits 5 alpha reductase

18

flutamide MOA

nonsteroidal competitive inhibitor at AR

19

ketoconazole MOA

inhibites seroid syntheisis @ 17, 20 desmolase

20

spironolactone MOA

inhibites steroid binding, 17 alpha hydroxylase, 17,20 desmolase

21

tamsulosin MOA

alpha 1 antqagonist

22

sidenafil/vardenafil/tadalafil MOA

inhibit PDE5

23

minoxidil MOA

direct arteriolar vasodilator

24

uses of leuprolide

moa = GnRH agonist
pulsatile: infertility
contiuous: prostate cancer after flutamide blocks ar
continous: uterine fibroids
continuous: precocious puberty

25

usese of ethinyl estradiol, DES and mestranol

ER agonists
hypogonadism or ovarina gailure
menstural abrnoamlities, HRT in post menopa
men with androgen dependent prostate cancer

26

use of clomiphene

inhibits ER at the hypothalamus
PCOS infertility treatmetn vrs anovulation

27

use of tamoxifen

antag at breast
ag at bone
ag at endo
to treat and prevent ER/PR positive breast cancer

28

use of raloxifen

antag at breast
ag at bone
antag at end
osteoporosis

29

use of HRT

prevent and reliefe menopausal symptoms
osteoporosis

30

use of anastrozole

aromatse inhibitors
postmenopausal women wit ER positive breast cancer

31

used of exemestane

aromatase inhibitors
postemenopausal women with ER posirive breast cnacners

32

use of progestins

PR ags
UCp
endometrial cancer
abnormal uterine bleeding

33

use of mifepristone

competitive inhibitor of PR
termination of pregos with misoprostal

34

use of terbutaline

b2 agonist
decreases freqency of contractions of women in labour

35

use of ritodrine

b2 agonist
decreases frequency of contractions of women in labour

36

use of danazol

synthetic androgen with partial agonist at androgen receptors
endometriosis
herediratary angioedema

37

uest of testosterone and metyhltestosterone

ag at AR
hypogonadism
promotes development of secondary sex characteristics
stimulatio of anablosim to recovery after burn and injuery

38

use of finasteride

5a reductased inhibitor
BPH
male patterened baldness

39

use of flutamide

nonsteroidal competitive inhibitor of AR
prostate carcinoma wtih leuprolide

40

use of ketoconazole

inhibites steroid synthesis/inhibits 17,20 desmolase
treat PCOS to reduce androgenic symptoms

41

use of spironolactone

inhibites steroid binding, 17 OHase, 17,2 desmolase
treats PCOS to reduces andogenic symptoms

42

use of tamsulosin

alpha1a/d antagonist
treast BPH

43

use of sildenafil/v ardenafil/tadalafil

inhibits PDE5
erectile dysfunction

44

use of minoxidil

direct arteriolar vasodiation
androgentic alopecia
severe refractory hyertension

45

toxo of minoxidil

direct arterial vasodilater
androgenic alopecia
severe refractory hypertension

46

toxo of sildenafil/vardenafil/tadalafil

inhibties pDe5
use at erectile dysfucntion
TOXO - headache, flushing, dysepsia, cyanopsia, hypotension with nitrates

47

toxo of tamsulosin

alpha1a/d antag
used at BPH
no toxo listed

48

toxo of spironolactone

inhibit steroid binding, 17 alpha OHase, 17, 20 desmolase
PCOS androgenic a/se
gynecomastia and amenorrhoea

49

toxo of ketoconazole

inhibits steroid synthesis, 17,20 desmolase
PCOS androgenic a/se
gynecomastia and amenorrhea

50

toxo of testosterone adn methyltestosteron

ag at AT
hypogonasdism, promotes development of secondary sexual characteristics, promotes healing @ anabolism in burns and injury

51

toxo of danazole

synthetic androgen, partial agnoist at androgen receptorp
@ endometriosis and hereditary angioedema
TOXO - weight gain, edema, acne, hirsutisim, masculinizaiton, decreased HDL levels and HEPATOTOXICITY

52

hepatotosicity

danazole

53

toxo fo terbutaline and riodrine

beta 2 agonists uterine relax
decreased freqeuncy of uterine contractions in labour
none listed

54

toxo of oral conctraceptvives

increased risk of vs in smokers over 35

55

toxo of mifepristone RU-486

progestin receptor competitive inhibitor
termination of pregos with misoprostol/PGE1
heavy bleeding, gi effects (n/a/anorexia), abdominal pain

56

toxo of progestin

progestin receptor agonist, decrease grwtoh and icnreases vascularization of endom
@ oral contraceptins, endometrial cancer and abnormal uterine bleeding

57

toxo of anastrozole

aromatase inhibit
used for postmenopausla women with ER positive breast cancer
no toxo listed

58

toxo of exemestane

aromatase inhibit
used in postmenopausal women with ER positive breast coancer
no toxo listed

59

toxo of raloxifene

antag breast
antag endo
ag bone
for osteoporosis
increased risk of thromboembooic events

60

toxo of tamoxifene

antag at breast
ag at bone
ag at endo
used at ER/PR breast cancer tx and prevent
toxo - icnreasd thromboemoblic events, icnreased endometrial cancer

61

toxo fo clomiphene

antag of ER at hypothalamus
infertility at PCOs by ovuation induction
hot flashes
ovarina enlargementh
multiple simultaneous pregos
visual disturbances

62

two drugs that can cause visual changes

clomiphene - hypothalalmus ER antag
sidenafil - cyanopsia inhibit PDE5

63

toxo of mestranol

ER agonist
hypogonadism or ovarina failure, menstrual abonromalties, HRT, men with androgen dependent prostate cancers
TOXO: increase risk of endometrial cancer, bleeding post menopausal woen, clear cella denomarcinom in vaigna, increase rick of thrmobi

64

where are mestranol, DES, ethinylestradiol contraindicated

Er positive breast cancer (treat with anastrozole and exemestane aromatse inhibitors)
historoy of DVT

65

toxo fo leuprolide

ag of GnRH
pulsatlie - infertility
continuous - precocious puberty, uterine fibroides, prostate cancer after AR blockade with flutamide
toxo: antiandrogen. n/v