Flashcards in Respiratory Deck (53)
Asthma is a chronic disease characterized by what?
COPD includes what two other diseases?
What kind of drug is Montelukast?
What are the 3 indications for Montelukast?
What is teh MOA os Montelukast?
Selectively binds to airway cysteinyl leukotriene receptors and blocks their stimulation by their endogenous ligands
What are the 5 common adverse effects of Montelukast?
What is the 1 serious adverse effect of Montelukast?
What are the 2 possible hypersensitivity reactions to Montelukast?
What provides quick relief for asthmatic patients?
Short acting beta-2 agonist
What kind of drug is Albuterol?
What are the 3 indications for Albuterol?
What is the MOA of Albuterol?
Selectively stimulates beta-2 adrenergic receptors, causing relaxation in airway smooth muscle
What are the 3 common adverse effects of Albuterol?
What are the 5 severe adverse effects of Albuterol?
What 4 drugs interact with Albuterol to cause Hypokalemia?
Albuterol may interact with Amphotericins, CAIs, Steroids, or Macrolides to produce what?
What 3 drugs interact with Albuterol to prolongate the QT interval?
If Albuterol interacts with Macrolides, Fluoroquinolones, or Azoles, what may occur?
QT interval prolongation
What may occur if Albuterol interacts with Sympathomimetic drugs?
What kind of drugs are the first choice for patients with any degree of persistent asthma?
What type of drug is Fluticasone?
What is the MOA of Fluticasone?
Acts through the classical steroid pathway, inhibiting arachidonic acid-based eicosanoid production
What are the 5 common adverse effects of Fluticasone?
What are the 5 serious adverse effects of Fluticasone?
Pediatric growth suppression
Nasal ulcer or septal perforation
What are the 3 ocular severe adverse effects of Fluticasone?
What type of drug is Salmeterol?
Steroid Combo - anti-inflammatory
What is the overall effect of Salmeterol?
What is the MOA of Salmeterol?
Beta-2 agonist that produces relaxation of airway smooth muscle
How is Salmeterol similar to Albuterol
It is a chemical analog with a lipophylic side chain to enhance duration of action