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Flashcards in Respiratory Deck (53)
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1

Asthma is a chronic disease characterized by what?

Hyper-responsive airways

2

COPD includes what two other diseases?

Emphysema
Chronic bronchitis

3

What kind of drug is Montelukast?

Leukotriene inhibitor

4

What are the 3 indications for Montelukast?

Asthma
Bronchospasm
Allergic rhinitis

5

What is teh MOA os Montelukast?

Selectively binds to airway cysteinyl leukotriene receptors and blocks their stimulation by their endogenous ligands

6

What are the 5 common adverse effects of Montelukast?

Headache
Flu-like symptoms
Puritis
Rash
Restlessness

7

What is the 1 serious adverse effect of Montelukast?

Thrombocytopenia

8

What are the 2 possible hypersensitivity reactions to Montelukast?

Erythema nadosum
Angioedema

9

What provides quick relief for asthmatic patients?

Short acting beta-2 agonist

10

What kind of drug is Albuterol?

Beta-2 agonist

11

What are the 3 indications for Albuterol?

Asthma
Bronchospasm
COPD

12

What is the MOA of Albuterol?

Selectively stimulates beta-2 adrenergic receptors, causing relaxation in airway smooth muscle

13

What are the 3 common adverse effects of Albuterol?

Cough
Dizziness
Headache

14

What are the 5 severe adverse effects of Albuterol?

Paradoxical bronchospasm
Hypertension
Angina
MI
Arrhythmias

15

What 4 drugs interact with Albuterol to cause Hypokalemia?

Amphotericins
CAIs
Steroids
Macrolides

16

Albuterol may interact with Amphotericins, CAIs, Steroids, or Macrolides to produce what?

Kypokalemia

17

What 3 drugs interact with Albuterol to prolongate the QT interval?

Macrolides
Fluoroquinolones
Azoles

18

If Albuterol interacts with Macrolides, Fluoroquinolones, or Azoles, what may occur?

QT interval prolongation

19

What may occur if Albuterol interacts with Sympathomimetic drugs?

Additive effect

20

What kind of drugs are the first choice for patients with any degree of persistent asthma?

Inhaled corticosteroids

21

What type of drug is Fluticasone?

Steroidal Anti-inflammatory

22

What is the MOA of Fluticasone?

Acts through the classical steroid pathway, inhibiting arachidonic acid-based eicosanoid production

23

What are the 5 common adverse effects of Fluticasone?

Headache
Cough
Pyrexia
Epistaxis
Nasopharyngitis

24

What are the 5 serious adverse effects of Fluticasone?

Adrenal suppression
Hypercorticism
Pediatric growth suppression
Nasal/oral candidosis
Nasal ulcer or septal perforation

25

What are the 3 ocular severe adverse effects of Fluticasone?

Cataracts
Glaucoma
Elevated IOP

26

What type of drug is Salmeterol?

Steroid Combo - anti-inflammatory

27

What is the overall effect of Salmeterol?

Bronchodilator

28

What is the MOA of Salmeterol?

Beta-2 agonist that produces relaxation of airway smooth muscle

29

How is Salmeterol similar to Albuterol

It is a chemical analog with a lipophylic side chain to enhance duration of action

30

What are the 6 common adverse effects of Salmeterol?

Headache
Nasal congestion
Rhinitis
Bronchitis
Urticaria
Tachycardia