Respiratory: COPD Flashcards Preview

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Flashcards in Respiratory: COPD Deck (11)
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1
Q

Where do M1 receptors act?

A

At the ganglia- the facilitate transmission mediated by ACh on nicotinic receptors

2
Q

Where do the M2 act?

A

Post ganglionic- reduce ACh production

3
Q

Where do M3 act?

A

Smooth muscle- mediate contraction to ACh

4
Q

What does activation of M3 receptors cause

A

coupling with Gq receptors activates phospholipase C which increases Calcium induced calcium release from SR and causes contraction

5
Q

Name two SAMAs

A

Ipratropium

Oxitropium

6
Q

Name two LAMAs

A

Tiotropium

Aclidinium

7
Q

Which one is non selective?

A

Ipratropium

8
Q

Whihc receptro do you not want to block

A

M2

9
Q

Name an ultra LAB

A

indacaterol

10
Q

What other drug can be used to control COPD?

A

Phosphodiesterase 4 inhibitors

11
Q

Name a PDE4 inhibitor

A

Rofumilast