Flashcards in Respiratory druuggss Deck (58):
1
list the first gen H1 receptor inhibitors
diphenhydramine
dimenhydrinate
chlorpheniramine
2
used of first gen H1 receptor inhibitors
allergies
motion sickness
sleeping aid
3
side effect of first gen H1 receptor inhibitors
sedation
antimuscarinic
anti alpha adrenergic
4
diphenhydramie
H1 blocker
5
dimenhydrinate
H1 blocker
6
chlorpheniramie
H1 blocker
7
list the second gen H1 inhibitors
-DINE
loratadine
fexofenadine
desloratadine
cetirazine
8
use of second gen H1 inhibitors
allergy
9
side effects of second gen H1 inhibitors
less sedation than H1 because less CNS entry
10
loratadine
second gen Hi blocker
11
fexofenadine
second gen H1 blocker
12
desloratadine
second gen H1 blocker
13
cetirazine
second gen H1 blocker
14
list the expectorants
guaifenesin, N-acetylcysteine
15
MOA guaifenesin
expectorant - thins respiratory secretions, no suppression of cough reflex
16
MOA N-acetylcystiene
mucolytic - breaks disulfide bonds in mucos - used at CH
also used in acetaminophen OD
17
guaifenesin
expectorant
18
N-acetylcysteine
expectorant
19
list the antitussives
dextromethorphan
20
MOA dextromethrophan
antag NMDA glutamate receptors
codeine analoug
21
risks of dextromethrophan
mild opioid effects when used in excess
mildl abuse potntia
SEROTONIN SYNDROME if used with other serotonergic drugs
22
serotonin syndrome
dextromethrophan
23
naltrexone for od of?
destromethrophan
24
nasal decongestants please
pseudoephedrine
phenylephrine
25
MOA pseudephedrine, pheynlephrine
alpha agonists - vasoconstriction
26
reduce hyperemia use?
pseudephedrine, pheynlephrine
27
reduce edema use?
pseudephedrine, pheynlephrine
28
open obstructed Eustachian tubes use?
pseudephedrine, pheynlephrine
29
make methamphetamine?
pseudephedrine, pheynlephrine
30
toxicity includes: hypertension, CNS stimulation/anxiety
pseudephedrine, pheynlephrine
31
list the pulmonary hypertensive drugs
bosentan - endothelin receptor antagonists
sildenafil - PDE-5 inhibitors
epoprostenol, iloprost - prostacyclin analogs
32
MOA bosentan
endothelin receptor antag - decreases pulmonary vascular resistance
33
toxicity of bosentan
hepatotoxicity (also zilueton)
34
MOA of sildenafil
inhibits cGMP PDE5 -- prolongs vasodilatory effects of NO
35
use of sildenafil
pulmonary hypertension
erectile dysfunction
36
MOA epoprostenol and iloprost
PGI2 analogues -- direct vasodilatory effects on pulmonary an systemic arterial vascular beds
inhibition of platelet aggregation
37
side effects of epoprostenol and iloprost
flushing
jaw pain
38
list the families of asthma drugs and names plase
b2 agonists - albuterol, salmeterol, formoterol
corticosteroids - gluticasone, budesonide
muscarinic antags - ipratropium, tiotropium
antiluekotriens - motelukast, zafirlukast, zileuton
omalizumba -
methylxanthines
39
dx of asthma
methacholine - M2 agnoist
40
MOA albuterol
b2 agonist - relazes bronchial smooth muscle
41
DOC at acute asthma exacerbation
albuterol
42
a/se salmeterol and formoterol
tremor
arrhythmia
43
DOC at prophylaxis asthma
salmeterol, formoterol
b2 agonist long acting
44
MOA fluticasone, budesonide
inactivates NFkB -- inhibited synthesis of virtually all cytokines
45
DOC for chronic asthma
fluticasone, budesonide
corticosteroids
46
MOA ipratropium
competitive block of M receptors - no bronchoconstriction
47
COPD treatment
ipratropium
tiotropium
48
MOA montelukast and zarfirlukast
block leukotriene receptors CysLT1
49
DOC at aspirin induced asthma
montelukast
zarfirlukast
block Lt receptors
50
MOA zileuton
5-lipoxygenase pathway inhibitor
no aa to leukoteinces
51
a/se of zileuton
hepatotoxic (bosentan)
52
MOA omalizumab
monoclonal anti IgE an -- binds unbound serum Ig E and blocks interaction with FCeR1
53
DOC at allergic asthma resistant to inhaled steroids (fluticasone, budesonide) and long term acting b2 agonists (salmeterol, formoterol)
omalizumba
monoclonal anti IgE
54
MOA theophylline
inhibits phosphodiesterase -- increase cAMP due to decreased levels of hydrolysis
55
what limits useage of theophylline and its a/se
narrow TI
cardiotoxity and nephrotoxicity
56
cardiotoxic and nephrotoxic
theophylline
a methylxanthine
57
how is theophylline metabolized
P450 system
58