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Flashcards in Respiratory druuggss Deck (58):
1

list the first gen H1 receptor inhibitors

diphenhydramine
dimenhydrinate
chlorpheniramine

2

used of first gen H1 receptor inhibitors

allergies
motion sickness
sleeping aid

3

side effect of first gen H1 receptor inhibitors

sedation
antimuscarinic
anti alpha adrenergic

4

diphenhydramie

H1 blocker

5

dimenhydrinate

H1 blocker

6

chlorpheniramie

H1 blocker

7

list the second gen H1 inhibitors

-DINE
loratadine
fexofenadine
desloratadine
cetirazine

8

use of second gen H1 inhibitors

allergy

9

side effects of second gen H1 inhibitors

less sedation than H1 because less CNS entry

10

loratadine

second gen Hi blocker

11

fexofenadine

second gen H1 blocker

12

desloratadine

second gen H1 blocker

13

cetirazine

second gen H1 blocker

14

list the expectorants

guaifenesin, N-acetylcysteine

15

MOA guaifenesin

expectorant - thins respiratory secretions, no suppression of cough reflex

16

MOA N-acetylcystiene

mucolytic - breaks disulfide bonds in mucos - used at CH
also used in acetaminophen OD

17

guaifenesin

expectorant

18

N-acetylcysteine

expectorant

19

list the antitussives

dextromethorphan

20

MOA dextromethrophan

antag NMDA glutamate receptors
codeine analoug

21

risks of dextromethrophan

mild opioid effects when used in excess
mildl abuse potntia
SEROTONIN SYNDROME if used with other serotonergic drugs

22

serotonin syndrome

dextromethrophan

23

naltrexone for od of?

destromethrophan

24

nasal decongestants please

pseudoephedrine
phenylephrine

25

MOA pseudephedrine, pheynlephrine

alpha agonists - vasoconstriction

26

reduce hyperemia use?

pseudephedrine, pheynlephrine

27

reduce edema use?

pseudephedrine, pheynlephrine

28

open obstructed Eustachian tubes use?

pseudephedrine, pheynlephrine

29

make methamphetamine?

pseudephedrine, pheynlephrine

30

toxicity includes: hypertension, CNS stimulation/anxiety

pseudephedrine, pheynlephrine

31

list the pulmonary hypertensive drugs

bosentan - endothelin receptor antagonists
sildenafil - PDE-5 inhibitors
epoprostenol, iloprost - prostacyclin analogs

32

MOA bosentan

endothelin receptor antag - decreases pulmonary vascular resistance

33

toxicity of bosentan

hepatotoxicity (also zilueton)

34

MOA of sildenafil

inhibits cGMP PDE5 -- prolongs vasodilatory effects of NO

35

use of sildenafil

pulmonary hypertension
erectile dysfunction

36

MOA epoprostenol and iloprost

PGI2 analogues -- direct vasodilatory effects on pulmonary an systemic arterial vascular beds
inhibition of platelet aggregation

37

side effects of epoprostenol and iloprost

flushing
jaw pain

38

list the families of asthma drugs and names plase

b2 agonists - albuterol, salmeterol, formoterol
corticosteroids - gluticasone, budesonide
muscarinic antags - ipratropium, tiotropium
antiluekotriens - motelukast, zafirlukast, zileuton
omalizumba -
methylxanthines

39

dx of asthma

methacholine - M2 agnoist

40

MOA albuterol

b2 agonist - relazes bronchial smooth muscle

41

DOC at acute asthma exacerbation

albuterol

42

a/se salmeterol and formoterol

tremor
arrhythmia

43

DOC at prophylaxis asthma

salmeterol, formoterol
b2 agonist long acting

44

MOA fluticasone, budesonide

inactivates NFkB -- inhibited synthesis of virtually all cytokines

45

DOC for chronic asthma

fluticasone, budesonide
corticosteroids

46

MOA ipratropium

competitive block of M receptors - no bronchoconstriction

47

COPD treatment

ipratropium
tiotropium

48

MOA montelukast and zarfirlukast

block leukotriene receptors CysLT1

49

DOC at aspirin induced asthma

montelukast
zarfirlukast
block Lt receptors

50

MOA zileuton

5-lipoxygenase pathway inhibitor
no aa to leukoteinces

51

a/se of zileuton

hepatotoxic (bosentan)

52

MOA omalizumab

monoclonal anti IgE an -- binds unbound serum Ig E and blocks interaction with FCeR1

53

DOC at allergic asthma resistant to inhaled steroids (fluticasone, budesonide) and long term acting b2 agonists (salmeterol, formoterol)

omalizumba
monoclonal anti IgE

54

MOA theophylline

inhibits phosphodiesterase -- increase cAMP due to decreased levels of hydrolysis

55

what limits useage of theophylline and its a/se

narrow TI
cardiotoxity and nephrotoxicity

56

cardiotoxic and nephrotoxic

theophylline
a methylxanthine

57

how is theophylline metabolized

P450 system

58

blocks action of adenosine

theophylline, a methylxanthine