Respiratory druuggss

Question 1

list the first gen H1 receptor inhibitors

Answer 1

diphenhydramine
dimenhydrinate
chlorpheniramine

Question 2

used of first gen H1 receptor inhibitors

Answer 2

allergies
motion sickness
sleeping aid

Question 3

side effect of first gen H1 receptor inhibitors

Answer 3

sedation
antimuscarinic
anti alpha adrenergic

Question 4

diphenhydramie

Answer 4

H1 blocker

Question 5

dimenhydrinate

Answer 5

H1 blocker

Question 6

chlorpheniramie

Answer 6

H1 blocker

Question 7

list the second gen H1 inhibitors

Answer 7

-DINE
loratadine
fexofenadine
desloratadine
cetirazine

Question 8

use of second gen H1 inhibitors

Answer 8

allergy

Question 9

side effects of second gen H1 inhibitors

Answer 9

less sedation than H1 because less CNS entry

Question 10

loratadine

Answer 10

second gen Hi blocker

Question 11

fexofenadine

Answer 11

second gen H1 blocker

Question 12

desloratadine

Answer 12

second gen H1 blocker

Question 13

cetirazine

Answer 13

second gen H1 blocker

Question 14

list the expectorants

Answer 14

guaifenesin, N-acetylcysteine

Question 15

MOA guaifenesin

Answer 15

expectorant - thins respiratory secretions, no suppression of cough reflex

Question 16

MOA N-acetylcystiene

Answer 16

mucolytic - breaks disulfide bonds in mucos - used at CH

also used in acetaminophen OD

Question 17

guaifenesin

Answer 17

expectorant

Question 18

N-acetylcysteine

Answer 18

expectorant

Question 19

list the antitussives

Answer 19

dextromethorphan

Question 20

MOA dextromethrophan

Answer 20

antag NMDA glutamate receptors

codeine analoug

Question 21

risks of dextromethrophan

Answer 21

mild opioid effects when used in excess
mildl abuse potntia
SEROTONIN SYNDROME if used with other serotonergic drugs

Question 22

serotonin syndrome

Answer 22

dextromethrophan

Question 23

naltrexone for od of?

Answer 23

destromethrophan

Question 24

nasal decongestants please

Answer 24

pseudoephedrine

phenylephrine

Question 25

MOA pseudephedrine, pheynlephrine

Answer 25

alpha agonists - vasoconstriction

Question 26

reduce hyperemia use?

Answer 26

pseudephedrine, pheynlephrine

Question 27

reduce edema use?

Answer 27

pseudephedrine, pheynlephrine

Question 28

open obstructed Eustachian tubes use?

Answer 28

pseudephedrine, pheynlephrine

Question 29

make methamphetamine?

Answer 29

pseudephedrine, pheynlephrine

Question 30

toxicity includes: hypertension, CNS stimulation/anxiety

Answer 30

pseudephedrine, pheynlephrine

Question 31

list the pulmonary hypertensive drugs

Answer 31

bosentan - endothelin receptor antagonists sildenafil - PDE-5 inhibitors epoprostenol, iloprost - prostacyclin analogs

Question 32

MOA bosentan

Answer 32

endothelin receptor antag - decreases pulmonary vascular resistance

Question 33

toxicity of bosentan

Answer 33

hepatotoxicity (also zilueton)

Question 34

MOA of sildenafil

Answer 34

inhibits cGMP PDE5 -- prolongs vasodilatory effects of NO

Question 35

use of sildenafil

Answer 35

pulmonary hypertension | erectile dysfunction

Question 36

MOA epoprostenol and iloprost

Answer 36

PGI2 analogues -- direct vasodilatory effects on pulmonary an systemic arterial vascular beds inhibition of platelet aggregation

Question 37

side effects of epoprostenol and iloprost

Answer 37

flushing | jaw pain

Question 38

list the families of asthma drugs and names plase

Answer 38

b2 agonists - albuterol, salmeterol, formoterol corticosteroids - gluticasone, budesonide muscarinic antags - ipratropium, tiotropium antiluekotriens - motelukast, zafirlukast, zileuton omalizumba - methylxanthines

Question 39

dx of asthma

Answer 39

methacholine - M2 agnoist

Question 40

MOA albuterol

Answer 40

b2 agonist - relazes bronchial smooth muscle

Question 41

DOC at acute asthma exacerbation

Answer 41

albuterol

Question 42

a/se salmeterol and formoterol

Answer 42

tremor | arrhythmia

Question 43

DOC at prophylaxis asthma

Answer 43

salmeterol, formoterol | b2 agonist long acting

Question 44

MOA fluticasone, budesonide

Answer 44

inactivates NFkB -- inhibited synthesis of virtually all cytokines

Question 45

DOC for chronic asthma

Answer 45

fluticasone, budesonide | corticosteroids

Question 46

MOA ipratropium

Answer 46

competitive block of M receptors - no bronchoconstriction

Question 47

COPD treatment

Answer 47

ipratropium | tiotropium

Question 48

MOA montelukast and zarfirlukast

Answer 48

block leukotriene receptors CysLT1

Question 49

DOC at aspirin induced asthma

Answer 49

montelukast zarfirlukast block Lt receptors

Question 50

MOA zileuton

Answer 50

5-lipoxygenase pathway inhibitor | no aa to leukoteinces

Question 51

a/se of zileuton

Answer 51

hepatotoxic (bosentan)

Question 52

MOA omalizumab

Answer 52

monoclonal anti IgE an -- binds unbound serum Ig E and blocks interaction with FCeR1

Question 53

DOC at allergic asthma resistant to inhaled steroids (fluticasone, budesonide) and long term acting b2 agonists (salmeterol, formoterol)

Answer 53

omalizumba | monoclonal anti IgE

Question 54

MOA theophylline

Answer 54

inhibits phosphodiesterase -- increase cAMP due to decreased levels of hydrolysis

Question 55

what limits useage of theophylline and its a/se

Answer 55

narrow TI | cardiotoxity and nephrotoxicity

Question 56

cardiotoxic and nephrotoxic

Answer 56

theophylline | a methylxanthine

Question 57

how is theophylline metabolized

Answer 57

P450 system

Question 58

blocks action of adenosine

Answer 58

theophylline, a methylxanthine