Respiratory I Flashcards Preview

Board Review - B - Systems Pharmacology > Respiratory I > Flashcards

Flashcards in Respiratory I Deck (37)
1

diphenhydramine

1st gen antihistamine

2

demenhydrinate

1st gen antihistamine

3

chlorpheniramine

1st gen antihistamine

4

H1 blocker

reversible inhibitor H1 receptors

5

loratadine

2nd gen antihistamine

6

fexofenadine

2nd gen antihistamine

7

desloratadine

2nd gen antihistamine

8

cetirizine

2nd gen antihistamine

9

adverse 1st gen antihistamine

sedation
antimuscarinic
anti-a-adrenergic

10

adverse 2nd gen antihistamine

far less - decreased entry to CNS

11

guaifenesin

expectorant - thins resp secretion

12

N-acetylcysteine

mucolytic - loosen mucous plug CF - disrupt disulfide bonds

also used antidote acetaminophen OD

13

dextromethorphan

antagonist NMDA receptor - glutamate

antitussive

synthetic codeine analog - mild opioid effects

14

pseudoephedrine

a-adrenergic agonist

nasal decongestant

15

phenylephrine

a-adrenergic agonist

nasal decongestant

16

adverse a-adrenergic agonists

HTN

17

bosentan

endothelin receptor antagonist

decreased pulmonary vascular resistance

18

sildenafil

PDE-5 inhibitor
-inhibit cGMP and prolong vasodilation of NO

tx ED and pulmonary HTN

19

epoprostenol

prostacyclin analog

vasodilatory effect

tx pulmonary HTN

20

iloprost

prostacyclin analog

21

adverse prostacyclin analogs

flushing
jaw pain

22

albuterol

short acting beta2 agonist

23

salmeterol

long acting beta2 agonist

24

formoterol

long acting beta 2 agonist

25

fluticasone

corticosteroid

inactivate NF-kB - decresed TNF-a

1st line tx chronic asthma

26

budesonide

corticosteroid

inactivate NF-kB - decresed TNF-a

1st line tx chronic asthma

27

ipratropium

muscarinic antagonist

prevent bronchoconstriction
-asthma drug

28

tiotropium

long acting muscarinic antagonist

29

montelukast

anti-leukotriene

aspirin induced asthma tx

30

zafirlukast

anti-leukotriene

aspirin induced asthma tx

31

zileuton

5-lipoxygenase pathway inhibitor

block converstion arachidonic acid to leukotriene

hepatotoxic

32

omalizumab

monoclonal IgE Ab
tx allergic asthma

33

theophylline

methylxanthine

causes bronchodilation
-inhibit phosphodiesterase
-increased cAMP

34

asthma early and late response

early - bronchoconstriction
late - inflammation

35

adverse theophylline

cardiotoxic
neurotoxic

narrow therapeutic window

block action of adenosine

36

ACh and adenosine

promote bronchoconstriction

37

methacholine

M3 agonist
-used in bronchial challenge test - help diagnose asthma