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Flashcards in respiratory viruses Deck (28):
1

what is the virus family, genome, and virion of influenza virus

family - orthomyxovirus
genome - segmented (-) ssRNA
virion - enveloped

2

what strain of the influenza virus most commonly is associated with humans

type A influenza

3

what does HA stand for, what virus has these, and what is its function

Hemagglutin protein in infulenza viruses
-used for cell attachment/entry

4

what does NA stand for, what virus has this, and what is its function

-Neuroamidas protein in the infuenza virus
-used for budding/release

5

what strain of influenza is known to have an animal resovoir

type A (waterfowl)

6

where does replication occur for Type A influenza ?

in the host nucleus (unique b/c most RNA virus replicate in the host cytoplasm)
-Type a genome is (-) ssRNA

7

What other viruses with are unique to the rule in that they hava a (-)ssRNA genome but replicate in the nucleus

HTLV-1 virus
HIV

8

how is Type A influenza transmitted and what is its incubation time

aersol droplets (fairly contagious)
-1 to 4 days incubation

9

what are the current circulating strains of seasonal influenza

H3N2, H1N1

10

Type A influenza can be prevented by administering a live attenuated vaccine, however this vaccine must be redeveloped each year, why ?

Antigenic shift, meaning the virus has rapidly changing proteins that can adapt evolve to become resistant

11

the live attenuated vaccine given to prevent influenza usually contains what strains ?

H3N2, H1N1, Type B strain

12

what influenza protein do antivirals amantidine and rimantidine block

Blocks M2 protein
-thus blocks nucleocapsid release/entry

13

what influenza protein does antiviral Tamiflu block

blocks NA (neuroamidase protein)
-thus blocking budding/release

14

what was the most deathly influenza pandemic recorded, and what type of strain was it ?

1918 Spanish Flu
H1N1 virus causing cytokine storm (caused deaths)

15

It is believed that influenza pandemics arise from ?

avian strains of influenza

16

what avian influenza strains are known as Highly Pathogenic Avian Influenza

H5 and H7 strains

17

What is the family, genome, and virion of adenovirus

family - adenoviridae
genome - dsDNA
virion - nonenveloped

18

Gene expression for adenovirus occurs in 3 stages, what are they ?

1 - intermediate-early : E1A
2- early : E1B and more
3 - late

19

Genome replication in adenovirus is unique in that in order to copy both ends of the genome, the displaced strand must ______ to allow template copies to be made

circularize
-remember its dsDNA

20

what protein of the adenovirus works in the intermediate-early stage of gene expression to inactivate pRB (which allows for replication to occur)

E1A

21

what protein of the adenovirus works in the early stage of gene expression to inactivate p53 (which allows for replication to occur )

E1B

22

the adenovirus has specific proteins that block _____ induced apoptosis, and the action of _______ which work in translation

-TNF (tumor necrosis factor)
-IFN alpha and IFN beta

23

The symptoms of what 2 virus are the same as the common cold ?

Adenovirus and Rhinovirus

24

why is the adenovirus frequently used for gene therapy

b/c it has a segmented genome which diff. proteins can be added to

25

acute respiratory disease (ARD) is associated w/ what virus

Adenovirus

26

what group of people are at an elevated risk for acute respiratory disease (ARD)

military

27

Which virus has a very large antigenic diversity which makes developing a vaccine very difficult

rhinovirus

28

what is the family, genome, and virion of the rhinovirus

family - picornavirus
genome - (+) ssRNA
virion - nonenveloped