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Flashcards in Review - GI Drugs Deck (24):
0

What types of medication may be useful in the treatment of GI?

1. Antacids
2. H2-blockers
3. PPIs
4. Prokinetic agents (cisapride, metoclopramide, bethanechol)
5. Mucosal protectants (sucralfate)

1

What is the mechanism of action of cisapride?

1. Increases lower esophageal sphincter pressure.
2. Accelerates gastric emptying.
3. Increases amplitude of esophageal contractions.
4. 5-HT4 agonist
5. 5-HT3 blocker

2

Which antacid can produce a metabolic alkalosis?

1. Sodium bicarbonate
2. Calcium carbonate

3

What causes the milk-alkali syndrome?

Ingestion of excessive amounts of calcium and absorbable alkali such as sodium bicarbonate or calcium bicarbonate.

4

Which H2 blocker can cause gynecomastia?

Cimetidine

5

What is an interesting side effect of PPIs?

People over 50 taking high doses of PPIs for more than a year were 2.6 times as likely to break a hip as were people not taking PPIs.

6

What is the most serious side effect of cisapride?

QT prolongation.

7

Meals worsen the pain associated with what type of ulcer?

Gastric

8

Meals relieve the pain associated with what type of ulcer?

Duodenal

9

What treatment options are available to eradicate H.pylori?

1. Triple therapy with a PPI added to 2 antimicrobial agents such as metronidazole amoxicillin, tetracycline, or clarithromycin.
2. Four drug regimens --> triple therapy + bismuth subsalicylate.

10

What happens in Reye syndrome?

Acute onset encephalopathy with fatty liver formation.

11

Which prostaglandin analog is commonly used as a cytoprotective agent for the treatment of PUD?

Misoprostol (synthetic PGE1 analog)

12

Sulfasalazine is cleaved by gut bacteria in the colon to produce what two compounds?

1. Sulfapyridine (sulfonamide antibiotic)
2. Mesalamine (5-ASA)

13

What type of vitamin supplementation should patients receive while on sulfasalazine?

Folic acid

14

What is the name of the monoclonal antibody indicated for the treatment of Crohn's disease?

Infliximab

15

True or false? Once remission has been achieved with ulcerative colitis, corticosteroids are used as maintenance therapy.

False. Steroids should be stopped due to high toxicity.

16

What is intractable emesis leading to dehydration and hypotension during pregnancy called?

Hyperemesis gravidarum

17

What are the drugs of choice for treating emesis during pregnancy?

1. Meclizine
2. Cyclizine
3. Promethazine

18

What antihistamine is often used to treat motion sickness?

Meclizine

19

What chemotherapy agent has one of the highest emetogenic potentials?

Cisplatin

20

What antidiarrheal can decrease tetracycline absorption if given concomitantly?

Bismuth salicylate.

21

What antidiarrheal is often formulated in combination with atropine?

Diphenoxylate

22

What medication is often used to treat flushing and diarrhea seen in carcinoid syndrome and VIP secreting tumors?

Octreotide

23

What types of medications cause constipation?

1. Opioids
2. Anticholinergics
3. Ca contains antacids
4. Aluminum-containing antacids
5. CCBs
6. Clonidine
7. Iron
8. Sodium polystyrene sulfonate

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