Rheum #1

Question 1

What is arthralgia

Answer 1

Perception of jt pain without obvious clinical findings

–May be referred pain from mm, tendon or bone

Question 2

What is HLA B27 associated w/ (4)

Answer 2

As
Reactive arthritis
Enteropathic arthritis
Psoriatic arthritis

Question 3

What is HLA DR4, DR1 associated w

Answer 3

Rheumatic arthritis

Question 4

What is HLA DR3 associated w

Answer 4

Sjogren syndrome

Systemic lupus erthematosus

Question 5

What are the seropositive inflammatory arthritis (5)

Answer 5

RA
SLE
scleroderma
DMM/PM
Sjorgens syndrome

Question 6

What are the signs of inflammatory arthritis

Answer 6

• Pain at rest + relieved by gentle motion
• morning stiffness >1hr
• Warmth/swelling etc

Question 7

What is the use of jt aspirations

Answer 7

Red swollen and painful its.

main differentials include gout, psuedogout and septic arthritis

Question 8

Autoantibodies in Ra

Answer 8

Rheumatoid factor + Anti CCP

Question 9

What are the 3 autoantibodies for SLE

Answer 9

Anti ds DNA
Anti Sm
Antibodies against RBCs, WBCs or platlets

Question 10

What are the antibodies agains Sjorgens syndrome

Answer 10

Anti Ro

Anti LA

Question 11

What is the antibody against drug induced SLE

Answer 11

Anti histone

Question 12

What is the antibody against CREST

Answer 12

anti centromere

Question 13

What is the antibody against PM/DMM

Answer 13

anti Jo1 (both)
Anti Mi 2 (DMM)

Question 14

What condition is related to positive C-ANCA (antineuotrophil cytoplasmic antibody)

Answer 14

granulomatosis with polyangitis (GPA) (Wegener’s Granulomatosis)

Question 15

What disease associated with positive p-ANCA

Answer 15

Churg-Strauss Syndrome

Question 16

part of hands unaffected in Rheumatoid Arthritis

Answer 16

DIPs and 1st carpal meta carpal

Question 17

What are the jt deformities seen in RA

Answer 17

Boutonnieres
Swan Neck
Ulnar deviation of fingers

Question 18

Sjogrens Syndrome definition

Answer 18

keratoconjunctivitis sicca + Xerostomia (dry eyes and mouth)

Question 19

Caplan’s Syndrome def

Answer 19

RA + Pneumoconiosis (manifests as multiple intrapulmonary nodules

Question 20

Very dangerous aspect of C-spine and Rheum Arthritis

Answer 20

Atlanto-axial (c1 and c2) subluxation (impingement, and damage to spinal cord)

Question 21

Felty’s Syndrome def

Answer 21

arthritis + Splenomegaly + Neutropenia

Question 22

what chart should i use for RA diagnosis and score needed

Answer 22

2010 ACR/EULAR criteira (6/10 is a definite score for RA)

Question 23

best initial test for RA

Answer 23

X ray

Question 24

Tx for RA

Answer 24

• early diagnosis and early intervention with DMARDs and biologics–> Methotrexate is gold standard

Exercise

Question 25

gold standard drug for RA

Answer 25

methotrexate

Question 26

What type of anemia would you expect to see with RA?

Answer 26

Low hemoglobin, then check MCV (mean corpuscle volume), concerned if MCV <80 for microcytic hyperchromic anemia!