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Flashcards in Rheumatology Deck (97):
1

What is rheumatoid factor?

an IgM against IgG Fc

2

What are tophi?

gout crystals + giant cells

3

What is podagra?

big toe inflammaiton

4

What is CREST syndrome?

C:calcinosis
R: Raynaud's
E: Esophageal dysmotility
S: Sclerodactyly
T: Telangiectasia

5

What Ab is assoc with CREST?

anti-centromere ab

6

What diseases have Raynaud's syndrome

scleroderma
Takayasu's
RA
SLE

7

What platelet count do most types of vasculitides have?

low platelets

8

Which vasculitis has a high platelet count?

Kawasaki disease

9

Which vasculitis has normal platelet count?

Henoch-Schonlein Purpura

10

What is osteoarthritis?

pain worse with activity
PIP/DIP joints

11

What is rheumatoid arthritis?

pain worse in morning
MCP/PIP joints

12

What is Still's disease?

juvenile RA

13

What is Pseudogout?

pyrophosphate crystals in knees and wrists

14

What is gout?

urate crystals in big toe
neg birefringence

15

What is myositis?

1 muscle hurts

16

What is polymyositis?

>1 muscle weak

17

What is dermatomyositis?

myositis + rash

18

What is fibromyalgia?

hurt all the time
11 trigger points

19

What is polymyalgia rheumatica?

weak shoulders
temporal arteritis

20

What is SLE (lupus)?

discoid rash

21

What is scleroderma?

tight skin
fibrosis

22

What is Takayasu Arteritis?

pulseless Asian women
aorta inflammation

23

What is Polyarteritis Nodosa?

p-ANCA Ab
attacks gut/kidney
Hep B

24

What is Wegner's Granulomatosis?

c-ANCA Ab
attacks ENT, lungs, kidney

25

What is Goodpasture's?

anti-GBM ab
attacks lung/kidney
RPGN

26

What is Reiter's syndrome?

males that can't see, can't pee, can't climb a tree

27

What is Sjogren's syndrome?

females that have dry eyes/mouth
RA

28

What is Behcet's syndrome?

oral and genital ulcers
uveitis

29

What is Churg-Strauss?

asthma
eosinohils
multi-organ involvement

30

What is Felty's syndrome?

RA
leukopeia
spenomegaly

31

What is Kawasaki's Disease?

CRASH
C: conjunctivitis
R: rash (palms/soles)
A: aneurysm (coronary artery--> MI in kids)
S: strawberry tongue
H: hot (fever >102 for at least 3 days + cervical lymphadenopathy)

32

What is the complication of temporal ateritis?

blindness

33

What is another name for temporal arteritis?

giant cell arteritis

34

How do you diagnose temporal arteritis?

temporal artery biopsy

35

What is the rule of 60's for temporal arteritis?

age>60
ESR>60
60mg prednisone to tx

36

What condition is assoc with one muscle hurting?

myositis

37

What condition is assoc with several muscles hurting?

polymyositis

38

What condition is assoc with musle pain plus rash?

dermatomyositis

39

What condition is assoc with inflamed muscle insertions?

fibrositis

40

What condition causes pain of muscle and muscle insertion?

fibromyalgia

41

What condition is assoc with shoulder girdle hurting most?

polymyalgia rheumatica

42

What condition is assoc with visceral cancer?

dermatomyositis (colon cancer)

43

What condition is assoc with Rifampin, INH, Statins,Prednisone, and hypothyroidism?

myositis

44

What condition is treated with amitriptyline?

fibromyalgia

45

What condition is increased in temporal arteritis?

polymyalgia rheumatica

46

What condition is assoc with multiple trigger points?

fibromyalgia

47

What condition is assoc with muscle pain when moving?

fibrositis

48

What condition is assoc with heliotropic rash?

dermatomyositis

49

What condition is assoc with a throbbing temporal headache?

temporal arteritis

50

What drugs cause myositis?

rifampin
INH
statins
prednisone

51

What disease causes myositis?

hypothyroidism

52

What is the treatment for multiple sclerosis?

#1 steroids
#2 blocking immunoglobulins (TNF-beta)
#3 plasmapheresis

53

What structure does MS like to attack

medial longitudinal fasciculus--> internuclear opthalmoplegia

54

What is the diagnosis for a middle aged woman with optic neuritis (eye problem)?

multiple sclerosis

55

What is the equivalent disease to MS in children

metachromatic leukodystrophy

56

What vasculitis occurs 2 wks after a common cold?

Berger's

57

What disease presents as a smoking Jew with necrotizing vasculitis?

Buerger's

58

What disease has a family history of deafness and cataracts?

Alport's

59

What vasculitis has a strawberry tongue?

Kawasaki's

60

What vasculitis has fibrin split products?

DIC

61

What vasculitis presents 2 wks after E. coli gastroenteritis?

hemolytic uremic syndrome

62

What vasculitis presents with fever, thrombocytopenia, and neuro problems?

ITP

63

What vasculitis attacks midsize arteries (particularly in GI and kidney)?

polyarteritis nodosa

64

What vasculitis affects the sinuses, lung, and kidney

Wegner's Granulomatosis

65

What vasculitis has linear immunofluorescence on GBM with lung involvement?

Goodpasture's

66

What vasculitis has pulmonary infiltrates with eosinophilia?

Churg-Strauss

67

What glomerulonephritis occurs two weeks after a sore throat?

Post-Strep Glomerulonephritis

68

What vasculitis presents two wks after vaccination?

serum sickness

69

What disease leads to septic emboli?

subacute bacterial endocarditis

70

What is the only vasculitis with a normal platelet count?

HSP

71

What is the only vasculitis with a high platelet count?

Kawasaki's

72

What is the MCC of death in SLE?

renal failure

73

What protein is decreased in all vasculitides?

haptoglobin

74

What cellular response is seen in all vasculitides?

T cells and macrophages

75

What are the clues for Kawasaki?

mucositis
rash on palms and soles
cervical lymph nodes
fever>102 for >3days

76

What are the clues for TTP?

fever
thrombocytopenia
neurologic problems

77

What are the clues for polyarteritis nodosa?

midsized arteries (GI and renal)
associated with Hep B
p-ANCA

78

What are the clues for Churg-Strauss?

allergic vasculitis

79

What are the clues for SBE?

caused by strep viridens

80

What are the clues for MPGN I?

tram tracks with C3 nephritic factor in basement membrane

81

What are the clues for MPGN II?

tram tracks with low complement (dense deposit disease)

82

What are clues for CREST?

mildest form of scleroderma
patchy involvement

83

What are the clues for scleroderma?

anti-scl70 Ab
anti-sm muscle Ab

84

What are clues for progressive systemic sclerosis?

scleroderma with organ involvement

85

What are clues for rheumatoid arthritis?

symmetrical polyarteritis
worse in morning

86

What are clues for juvenile rheumatoid arthritis?

arthritis with iridesis

87

What are clues for Felty's?

RA + leukopenia + splenomegaly

88

What are clues for Behcet's?

RA + GI ulcers

89

What are clues for Sjogren's?

RA + dry eyes, dry mouth

90

What is the vasculitis with GI bleeding, intussusception, and normal platelet count?

HSP

91

What is the vasculitis whose most common cause of sepsis?

DIC

92

What is the most common cause of renal failure in children?

HUS

93

What is the vasculitis with which Hep B is assoc with?

PAN

94

What vasculitis causes pulmonary infiltrate with eosinophilia?

Churg-Strauss

95

What vasculitis has xerophthalmia and xerostomia?

sjogren's

96

What is the most common cause of arthritis in a middle aged female?

rheumatoid arthritis

97

What is the only arthritis that attacks the synovium?

rheumatoid arthritis