rheumatology- CORTEX

Question 1

arthropy definition

Answer 1

disease of joint

Question 2

arthritis definition

Answer 2

inflammation of the joint

Question 3

arthralgia definition

Answer 3

describes pain in joint

Question 4

what are the two main categories of arthritis?

Answer 4

non inflammatory

inflammatory

Question 5

what is the most common type of non inflammatory arthritis?

Answer 5

osteoarthritis

Question 6

what can inflammatory arthritis be divided into?

Answer 6

seropositive arthritis

seronegative arthritis

Question 7

give examples of common seronegative arthritis?

Answer 7

• ankylosing spondilitis
• psoriatic arthritis
• reactive arthritis
• enteropathic arthritis

Question 8

give examples of seropositive arthritis

Answer 8

• RA
• lupus
• scleroderma
• vasculitis
• Sjogren’s

Question 9

what does seropositive mean?

Answer 9

auto antibodies present in serum

Question 10

what is anti-CCP antibody associated with?

Answer 10

RHEUMATOID ARTHRITIS!!!!!!

anti-CCP (anti-cyclic citrullinated peptide)

CCP= can cause polyarthritis (RA)

Question 11

what is ANA (anti nuclear antibody) associated with?

Answer 11

• SLE
• Sjogrens syndrome
• Systemic sclerosis
• MCTD (mixed connective tissue disorder)
• Auto immune liver disease

Question 12

what is Anti- double stranded DNA antibody (anti dsDNA) associated with?

Answer 12

SLE

Question 13

what is anti-SM associated with?

Answer 13

SLE

Question 14

what is anti-Ro associated with?

Answer 14

SLE
Sjorens syndrome

SLE= affects middle aged women= aunty Ro :(

Sjorens= 9x more likely to be developed by women than men= aunty Ro again :(

Question 15

what is Anti-La associated with?

Answer 15

Sjoren’s syndrome

Anti-La= anti sALiva= sjorens syndrome affects parts of body that produce fluid eg saliva, tears

Question 16

what is anti- centromere antibody associated with?

Answer 16

limited systemic sclerosis

Question 17

what is anti-scl-70 antibody associated with?

Answer 17

diffuse systemic sclerosis

Question 18

what is anti-RNP antibody associated with?

Answer 18

• SLE

- MCTD

Question 19

whst is anti-Jo associated with?

Answer 19

Myositis

Question 20

what is anti-cardiolipin antibody and lupus anti-coagulant associated with?

Answer 20

anti-phospholipid syndrome

Question 21

what is anti-neutrophil cytoplasmic antibody (ANCA) associated with?

Answer 21

small vessel vasculitis

GPA, EGPA, MPA

Question 22

what is the most common form of arthritis?

Answer 22

osteoarthritis

Question 23

what is typically seen on an Xray in osteoarthritis?

Answer 23

LOSS
Loss of joint space
Osteophytes (bony lumps that grow on the bone)
Sclerosis (hardening)
Subchondral cysts

Question 24

what causes osteoarthritis?

Answer 24

-an imbalance between the cartilage being worn down and the chondrocyte repairing it

Question 25

what increases the risk of getting OA?

Answer 25

• increase in age
• obesity
• trauma
• being female
• family history

Question 26

how does OA present?

Answer 26

-joint pain and stiffness which is worsened by activity

Question 27

what joints are commonly affected by OA?

Answer 27

synovial joints

most commonly:

• hips
• SI joints
• knees
• DIPS
• MCP
• wrist
• cervical spine

Question 28

what are some signs of OA?

Answer 28

• heberdens nodes in DIPs
• bouchards nodes in PIPs
• weak grip
• reduced range of motion
• squaring at the base of the thumb at the carpo metacarpal joint

Question 29

how is OA diagnosed?

Answer 29

Most of the time its a clinical diagnosis

Can do Xray (LOSS)

Question 30

what are some signs of osteoarthritis in the knee?

Answer 30

• crepitations
• osteophytes
• effusion
• stiffness
• deformity
• bakers cyst in popliteal fossa

Question 31

where would pain be felt if there was OA in the hip?

Answer 31

-pain in groin and/or knee