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Flashcards in Rhythm is gonna get you Deck (32):
1

Quinidine

Class IA

Toxicity: Cinchonism (HA, tinnitus)

2

Procainamide

Class IA

Toxicity: Reversible SLE-like syndrome

3

Disopyramide

Class IA

4

Lidocaine

Class IB

5

Mexiletine

Class IB

6

Tocainide

Class IB

7

Flecainide

Class IC

8

Propafenone

Class IC

9

Class IA MOA

Na+ channel blocker

Increases AP duration, increases effective refractory period, & increases QT interval

Affect both atrial & ventricular arrhythmias, especially reentrant & ectopic supraventricular & ventricular tachycardia

Toxicity: Thrombocytopenia; torsades de pointes

Double Quarter Pounder

10

Class IB MOA

Na+ channel blocker

Decreases AP duration

Preferentially affect ischemic or depolarized Purkinje & ventricular tissue. Useful in acute ventricular arrhythmias (esp post-MI) & digitalis-induced arrhythmias

Toxicity: Local anesthetic; CNS stimulation/ depression, cardiovascular depression

Lettuce, Tomato, Mayo

11

Class IC MOA

Na+ channel blocker

No effect on AP duration

Useful in VTachs that progress to VF & in intractable SVT. Usually only used as last resort in refractory tachyarrhythmias. For pts w/o structural abnormalities

Toxicity: proarrhythmic, especially post-MI. Significantly prolongs refractory period in AV node

More Fries Please

12

Which class is affected by hyperkalemia?

Hyperkalemia causes increased toxicity for all class I drugs

13

Propanolol

Non-selective beta blocker

14

Esmolol

Selective beta blocker

15

Metoprolol

Selective beta blocker

SE: Dyslipidemia

16

Atenolol

Selective beta blocker

17

Timolol

Non-selective beta blocker

18

Carvedilol

Beta blocker

19

Acebutolol

Selective beta blocker

20

Class II MOA

Beta blockers

Decreases cAMP, decreases Ca2+ currents

Suppresses abnormal pacemakers by decreasing slope of phase 4. AV node particularly sensitive. Prolongs PR interval

Used for VTach, SVT, slowing ventricular rate during atrial fibrillation & atrial fibrillation

Toxicity: impotence, asthma exacerbation, cardiovascular effects (bradycardia, AV block, CHF), CNS effects (sedation, sleep alteration). May mask signs of hypoglycemia

Treat OD w/ glucagon

21

Ibutilide

K+ channel blocker

Toxicity: Torsades

22

Sotalol

K+ channel blocker

Toxicity: torsades de pointes, excessive beta block

23

Bretylium

K+ channel blocker

Toxicity: New arrhythmias, hypotension

24

Amiodarone

K+ channel blocker
BUT has class I, II, III, & IV effects b/c it alters lipid membrane

Toxicities: Pulmonary fibrosis, hepatotoxicity, hypothyroidism/hyperthyroidism, corneal deposits, skin deposits (blue/gray) resulting in photodermatitis, neurologic effects, constipation, cardiovascular effects (bradycardia, heart block, CHF)

25

Dofetilide

K+ channel blocker

26

Class III MOA

K+ channel blocker

Increases AP duration, increases effective refractory period. Used when other antiarrhythmics fail. Prolongs QT interval

27

Verapamil

Class IV
Cardioselective Ca2+ channel blocker

28

Diltiazem

Class IV

29

Nifedipine

Class IV
Selective for peripheral vasculature

30

Class IV

Ca2+ channel blockers

Decreases conduction velocity, increases effective refractory period, prolongs PR interval

Used to prevent nodal arrhythmias (Ie SVT)

Toxicity: Constipation, flushing, edema, CV effects (CHF, AV block, sinus node depression)

31

Adenosine

Increases K+ efflux out of cells --> hyperpolarizing the cell

Drug of choice in diagnosing/abolishing SVT

Very short acting (~15 sec)

Toxicities: flushing, hypotension, chest pain

Effects blocked by theophylline

32

Mg2+

Effective in torsades de pointes & digoxin toxicity