RLS USMLE Flashcards Preview

Rate limiting steps > RLS USMLE > Flashcards

Flashcards in RLS USMLE Deck (13)
Loading flashcards...
1
Q

Glycolysis

A

PFK-1

Positive Regulator AMP, F2,6BP

Negative Regulator: ATP and Citrate

2
Q

Gluconeogenesis

A

F 1,6 BP

Positive: N/A

Negative: AMP, F2,6BP (same as glycolysis activators!)

3
Q

TCA cycle

A

Isocitrate Dehydrogenase

Positive: ADP

Negative: ATP and NADH (Alcohol shuts down TCA)

4
Q

Glycogenogenesis

A

Glycogen Synthase

Positive: Glucose-6-P, Insulin, and Cortisol(counter-intuitive e)

Negative: Epi and Glucagon

5
Q

Glycogenolysis

A

Glycogen phosphorylase

Positive: Epi, Glucagon, AMP

Negative: Glucose-6-P, Insulin, ATP

6
Q

HMP Shunt

A

G6PD

Positive: NADP

Negative NADPH

7
Q

De novo pyrimidine synthesis

A

CPS II

Positive: ATP (have purines –> make pyrimidines) and PRPP

Negative: UTP (have pyrimidines)

8
Q

De novo purine synthesis

A

Glutamine-PRPP amidotransferase

Negative: AMP, IMP, and GMP (Low energy/Have Purines)

9
Q

Urea Cycle

A

Carbamoyl phosphate synthetase I

Positive: N-acetylglutamate (NAG)

10
Q

Fatty Acid Synthesis

A

Acetyl-CoA Carboxylase (ACC)

Positive: Insulin and Citrate

Negative: Glucagon and Palmitoyl CoA

11
Q

Fatty Acid Oxidation

A

Carnitine Acyltransferase I

Negative: Malonyl-CoA

12
Q

Ketogenesis

A

HMG-CoA Synthase

13
Q

Cholesterol Synthesis

A

HMG-CoA Reductase

Positive: Insulin, thyroxine

Negative: Glucagon, cholesterol