RNA Virus

Question 1

What are the types of Picornaviruses

Answer 1

Enterovirus
Rhinovirus
Hepatovirus
Cardiovirus
Aphthovirus

Question 2

Hepatovirus example

Answer 2

Hepatitis A virus

Question 3

Cardiovirus example

Answer 3

Encephalomyocarditis virus
Human porechovirus

Question 4

Example of Apthovirus

Answer 4

Foot-hand-mouth virus

Question 5

How is the genome of Picornaviruses

Answer 5

+ ss RNA — able to act as mRNA when it enters to cell

Question 6

What is the major receptor for Poliovirus

Answer 6

CD155

Question 7

What are the examples of Enterovirus

Answer 7

Poliovirus
Human Enterovirus A,E
Coxockieviruses A,B
Echoviruses

Question 8

Examples of Rhinovirus

Answer 8

Human rhinovirus A,B

Question 9

Whic family of viruses have Lytic Infection

Answer 9

Picornaviruses

Question 10

Non-Enterovirus diseases

Answer 10

Coxcakievirus A
Coxcakievirus B
Echoviruses
Enterovirus 70
Enterovirus 71

Question 11

Features of Enteroviruses

Answer 11

PH range 3-10
Small intestine is the major invasion site
Resistant to acidic pH
Replicate best at=37 Celsius

Question 12

Features of Rhinovirus

Answer 12

Ph= 6-8
Sensitive to acidic pH
Optimally replicate at = 33 Celsius

Question 13

Which Picornavirus cannot reach to stomach

Answer 13

Rhinovirus bc it is sensitive to the acidic pH

Question 14

How is the transmission of Enteroviruses

Answer 14

Ingestion of fecally infected material
Respiratory route

Question 15

Where does Enterovirus replicate at

Answer 15

Susceptible tissues of phayrinx or gut
Lymphoid tissue of the small intestine
Reticuloendothelial tissue

Question 16

Where does Enterovirus gives rise to minor and major viremia

Answer 16

Minor= regional lymph node
Major= Reticuloendothelial tissue

Question 17

What is Poliomyelitis

Answer 17

Caused by Poliovirus( Enterovirus— Picornavirus)
3 stereotypes = PV1,PV2,PV3
Minimal heterotypic immunity
1 in 200 infections leads to irreversible paralysis
Vaccines = IPV, OPV

Question 18

What does Coxcakievirus A causes

Answer 18

Herpangina
Hem. Conjunctiva A24
Hand foot mouth disease

Question 19

What does Coxcakievirus B causes?

Answer 19

Myocarditis
Pericarditis

Question 20

What does Echovirus causes

Answer 20

Aseptic meningitis

Question 21

What does Enterovirus 70 causes

Answer 21

Hem. Conjunctivitis

Question 22

What does Enterovirus 71 causes

Answer 22

CNS disease
Hand foot mouth disease

Question 23

Features of Rhabdoviruses

Answer 23

Neurotropic virus
Enveloped
SsRNA

Question 24

How is the rabies best spreaded

Answer 24

When the bite of the infected animal is deep enough to allow the virus to reach the deep skeletal muscle.

Question 25

How is the transmission of Rhinovirus

Answer 25

Aerosols Direct contact

Question 26

How is the genome of Rhabdoviruses

Answer 26

GpG Bullet-shaped Enveloped M protein N protein L protein P protein Helical Nucleocapsid

Question 27

How is the Initial infection of Rhabdoviruses

Answer 27

Replication in muscle or subepi Spreads to nerves by binding to Ach receptors

Question 28

What are the stages of Classical Rabies

Answer 28

Prodromal stage=fever,headache,malaise.. Sensory excitation stage=hyperactivity,hallucinations.. Coma and paralysis phase=paralysis and respiratory problems, death

Question 29

What is the post-exposure vaccine to Rabies

Answer 29

Human Diploid Cell Vaccination

Question 30

How is the genome of Reovirus

Answer 30

Non enveloped DsRNA-segmented

Question 31

Which virus is the agents of Viral Gastroentritis in children

Answer 31

Rotavirus

Question 32

Features of Rotavirus

Answer 32

Very stable Remain infective Resistant to acidic pH 11 gene segments Three concentric capsid

Question 33

Which viruses are in the family of Reovirus

Answer 33

Rotavirus Orthoreovirus Coltivirus Orbivirus

Question 34

What are the gene segments of Rotavirus

Answer 34

VP7 — G glycoprotein —— Genotypes: G1P,G2P,G3P,G4P,G9P VP4— P protease sensitive ——Serogroups: A,B,C,D,E,F (inner core structural proteins)