Flashcards in Rock Vitamins Water Soluble Deck (43):
What are the 8 B complex vitamins?
What are the functions of the B-complex vitamins?
Folate = blood cell production, embryonic development
Vitamin B6 = blood cell production, skin/neural fxns
Riboflavin = blood cell production, mucosal/skin fxns
Vitamin B12 = blood cell production, neural fxns
Thiamin = neural + CV fxns
Niacin = skin, neural and GI functions
Biotin = hair growth, skin/neural functions
Pantothenic acid = neural functions
What it's the function of vitamin C?
What enzyme carries out the synthesis of DNA precursor?
THF = tetrahydrofolate
What enzymes carries out DNA methylation for one-carbon metabolism?
Deficiencies in which vitamins become more apparent in rapidly proliferating cells (bone marrow, intestine, skin, immune system)?
What are sources of folate?
Green leafy vegetables
Fortified grain products
What is folate involved in?
Methylation reactions (one carbon metabolism)
What are causes of folate deficiency?
Chronic inflammatory diseases
Drugs with anti-folate activity = antieliptics
Is there luminal digestion of folate?
What carries out apical epithelial uptake of folate?
Proton-coupled folate transporter
What carries out basolateral epithelial release?
Multidrug resistance protein 3
Is there luminal digestion of vitamin B6?
Is there apical and basolateral uptake/release of vitamin B6?
Is there luminal digestion of riboflavin?
What is behind apical epithelial uptake of riboflavin?
Riboflavin transporter 3
What is behind basolateral epithelial release of riboflavin?
Riboflavin transporter 1
Is there luminal digestion of vitamin B12?
What is responsible for apical epithelial uptake and basolateral epithelial release of vitamin B12?
MDR protein 1
Is there luminal digestion of vitamin C?
What is responsible for apical epithelial uptake and basolateral epithelial release of vitamin C?
Na-dependent vitamin C transporter 1
Na-dependent vitamin C transporter 2
Is there luminal digestion of thiamin?
What are symptoms of folate deficiency?
Pregnancy complications (preeclampsia..)
Impaired fetal growth
Describe folate toxicity
But may mask vitamin B12 deficiency
What DDIs are associated with folate?
Antifolate drugs = MTX
Anticonvulsants and sulfonamides
What are sources of vitamin B6?
Starchy veggies = potatoes
Fruits = 🍌
What are symptoms of B6 deficiency?
Describe vitamin B6 toxicity
Can cause headache, sleepiness, tingling, neuropathy
What are symptoms of riboflavin deficiency?
Often associated with other micronutrient diseases
Toxicity associated with riboflavin?
Which water soluble vitamins have no toxicity associated with them?
What is another name for vitamin B12?
Where is vitamin B12 synthesized?
Only in bacteria and archaea
What are symptoms of vitamin B12 deficiency?
Megaloblastic anemia (like folate deficiency)
Neurological Sx: numbness, cognitive changes - caused by nerve degeneration
What are symptoms of vitamin C deficiency ?
Bleeding and inflammation - gum, skin, joints, peritoneum
Bone weaknesses and fractures
Impaired wound healing
Describe vitamin C toxicity
Excess iron absorption
What are causes of thiamin deficiency?
What are symptoms of thiamin deficiency?
Neurological = memory loss, pain, neuropathy
Neurological + CV = tachycardia, HF
What is a name for niacin deficiency?
What are symptoms of niacin deficiency?
Describe niacin toxicity
High doses = AEs =
Skin flushing, itching, tingling
What are symptoms of biotin deficiency?