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BFI: ADME > Routes of administration > Flashcards

Flashcards in Routes of administration Deck (15)
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1
Q

How do you choose the appropriate route of administration?

A
Site of infection
Which microorganism is responsible
Susceptibility of micro-organism
Pharmacokinetic limitations of the drug 
Status of the patient (emergency treatment, compliant, pre-existing disease / medications)
2
Q

Disadvantage of neomycin sulphate

A

Poorly absorbed on oral administration

Drug limited to GI Tract

3
Q

Intrathecal injection

A

Injection into sub-arachnoid space in spinal column

- solution/suspension

4
Q

Advantage of Intrathecal route

A
Bypasses BBB (blood-brain barrier)
Direct access to CNS
5
Q

Disadvantage of Intrathecal

A

Requires technically skilled staff
Not suitable for many drugs or additives to formulations
Sterility is essential

6
Q

Where are most drugs absorbed

A

Small intestines (duodenum)

7
Q

What does passive diffusion depend on

A

Lipophilicity

8
Q

What limits bioavailability of orally-delivered drugs

A

First-pass metabolism

9
Q

What form for drug to be absorbed

A

Uncharged

10
Q

What formulation is used for rectal administration?

A

Suppositories (solutions, suspensions, solid)

11
Q

Advantage of rectal route

A

Avoids first-pass metabolism
Avoids oral route problems (vomiting, GI disease)
Useful in patients who struggle with oral route (children)

12
Q

Disadvantage of rectal route

A

Lower bioavailability compared to oral route

13
Q

Intraveous injection

A

Injection into vein

14
Q

Subcutaneous injection

A

Injection into adipose tissue

15
Q

Intramuscular injection

A

Injection into muscle parenchyma