RX immuno Flashcards Preview

PHD buzzwords > RX immuno > Flashcards

Flashcards in RX immuno Deck (34):
1

coarse facies, eczema, retained primary teeth, abscesses due to failure to produce?

IL-17 (hyper IgE)

2

SCID results are failure to produce?

MHCII

3

bone marrow transplant, after several week has rash and diarrhea: what immuno cells/factors are cause?

Alloreactive donor T-lymphocytes (GVHD)

4

IL associated w/ acute phase rxn

IL6 (produced by T-lymph and macrophages)

5

where in the cell do proteins bind to MHC1

lumen RER

6

when a T lymphocyte recieves 1st signal MHC but not second, what occurs

anergy

7

GI infections->hyperplasia peyer patches which do what?

take up antigens and present them to B-cells which then secrete IgA

8

HLA associated with ulcerative colitis

HLA-B27

9

autoimmune disorder of peripheral myelination with muscle weakness in distal lower and ascends symmetrically, curved gram - rods: what bacteria

campylobacteri jejuni

10

endotoxin for n. menigitidis

lipooligosaccharide (LOS)

11

contact dermatitis can have false PDD BC?

both type IV HSR

12

goodpasture results in what histologically

linear antibody deposition along glomular basement membrane

13

name inactivated vaccines

Rabies, Influenza (inj), Polio (salk), Hep A (Rest In Peace Always)

14

TX for Bruton's agammaglobulinemia

Intravenous immunoglobin

15

TX for infant w/ hemolytic dz

exchange Rh-Pos for Rh neg blood

16

what are the antigen presenting cells

dendritic cells, macrophages, B-cells

17

fever, migratory joint pain, chorea, subcutaneous nodules, heart murmur, ddx?

Rheumatic fever from strep

18

streptococcal antigens is presented on__

MHCII (w/ 2 alpha and two beta chains)

19

pt w/Leukocyte adhesion def lacks protein ___ for neutrophil migration

LFA-1

20

Serum sickness=HSR?

Type III

21

passive immunizations

tetanus, botulism, hepatitis B, varicella, rabies

22

tx for myathenia gravis

endrophonium (inhibitor of acetylcholinesterase)

23

pernicious anemia co-occurs with hashioto thyroiditis is associated with HLA

HLA-DR5

24

why can autoimmune gastritis lead to pernicious anemia

antibodies that interfere with parietal cell secretion of intrinsic factor

25

EBV infects what type of cell

B cells and epithelial cells

26

Type IV HSR: pt has prior exposure to antigen which trigger the differentiation of ___into___

CD4+ T lymph to T-helper1

27

pemphigus vulgaris dz against

intracellular jxns bt epidermal cells (desomsomes)

28

hereditary hemochromatosis=increase

serum transferrin, serum iron, ferritin, (total iron capacity decrease

29

tingling, numbness of arm, blurry vision, fatigue, decrease sensation of extremities: tx?

Beta-interferon (IFN-B) bc MS

30

spider angiomas, frequent falls, IgA def; cause?

defect in DNA repair enzymes (ataxia-telangiectasia)

31

normocytic anemia, ptosis, double vision, muscle fatigue ddx?

myasthenia gravis

32

mycobacterium leprae is controlled by

Th1 cells which secrete interferon-gamma

33

recurrent pyogenic infections, ezcema, throbocytopenia what Ig low?

IgM (Wiskott-aldrish syndrome)

34

dry eye, dry motuh, arthritis, : antibody associated

anti-SSA and anti-SSB (Sjogren syndrome)