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Ryan's shit list - Step 1 > Ryan's Shit list - Immuno > Flashcards

Ryan's Shit list - Immuno Flashcards

(55 cards)

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1
Q

IL-8

A

Major chemotactic factor for neutrophils; increases phagocytosis in neutrophils

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2
Q

Lectin Compliment pathway

A

Mannose or other sugars on microbe surface –> C1-Like complex

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3
Q

C3b

A

Opsonization

Clearance of immune complexes

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4
Q

C3a

A

Anaphylaxis (C3a, 4a, 5a)

Neutrophil chemotaxis

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5
Q

C4a

A

Anaphylaxis (C3a, 4a, 5a)

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6
Q

C5a

A

Anaphylaxis (C3a, 4a, 5a)

Neutrophil chemotaxis

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7
Q

Helper T cells Markers

A

TCR, CD3, CD28, CD4, CD40L

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8
Q

Cytotoxic T cells Markers

A

TCR, CD3, CD28, CD8

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9
Q

Regulatory T cells Markers

A

TCR, CD3, CD28, CD4, CD25, FOXP3

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10
Q

B Cells Markers

A

CD19, CD20, CD21, CD40, Ig(M), MHC II, B7,

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11
Q

Macrophages Markers

A

CD4, CD14 (TLR4; binds endotoxin), CD40, MHC II, B7, Fc, C3b

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12
Q

NK Cells Markers

A

CD16 (binds Fc of IgG), CD56 (unique marker)

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13
Q

Antigenic variation (3 bac, 3 virus, 1 parasite)

A 
Salmonella (2 flagella)
Borrelia recurrentis
N. Gonorrhoeae (pilus protein)
Influenza, HIV, HCV
Trypanosomes
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14
Q

Treat with Passive Ig

A

Tetanus toxin, Botulinum toxin, HBV, Varicella, Rabies virus,

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15
Q

Alternative pathway compliment (spontaneous and microbial surfaces) –>

A

C3 –> C3Bb –> C3Bb3b

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16
Q

Lectin (microbial surfaces) –>

A

C1-Like Complex –> C4b –> C4b2b –> C4b2b3b

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17
Q

Classic (antigen-antibody:IgM/G complexes)–>

A

C1 –> C4b + C2b –> C4b2b –> C4b2b3b

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18
Q

Allergic reaction

A

T1 hypersensitivity –> Urticaria, pruritis, wheezing, fever (treat with antihistamines)

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19
Q

Anaphylactic reaction

A

Severe allergic reaction: Dypnea, bronchospasm, hypotension, respiratory distress, shock

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20
Q

Anti-centromere Ab

A

Limited Scleroderma (CREST)

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21
Q

Anti-Glutamic acid decarboxylase

A

DM Type 1

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22
Q

Anti-Histone

A

Drug induced lupus

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23
Q

Anti-Jo, Anti-SRP, anti-Mi-2

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A

Polymyositis, Dermatomyositis

24
Q

Anti-Mitochondrial

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A

Primary Biliary Cirrhosis

25
Anti-DNA Topoisomerase 1
Scleroderma (Diffuse)
26
Anti-Smooth muscle
Autoimmune Hepatitis
27
Anti-Ro, Anti-La
Sjogren syndrome
28
Anti-U1-RNP (ribonuclear protein)
Mixed connective tissue disease
29
IgA anti-endomysial, IgA anti-tissue transglutaminase
Celiac disease
30
MPO-ANCA / p-ANCA
Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (churg-strauss syndrome)
31
PR3-ANCA / c-ANCA
Granulomatosis with polyangitis (Wegener)
32
E- Selectin
Sialyl Lewis (Margination and rolling)
33
P-Selectin
Sialyl Lewis (Margination and rolling)
34
GlyCAM-1, CD34
L-Selectin (Margination and rolling)
35
ICAM-1 (CD54)
CD11/18 Integrins (LFA-1, Mac-1) (Tight adhesion)
36
VCAM-1 (CD106)
VLA-4 Integrin (Tight adhesion)
37
PECAM-1 (CD31)
PECAM-1 (CD31) (Diapedesis)
38
Secreted Cytokines by Macrophages
IL-1, IL-6, IL-8, IL-12, TNF-alpha
39
Secreted cytokines by T cells
IL-2, IL-3
40
Secreted Cytokines by Th1 Cells
IFN-Gamma
41
Secreted Cytokines by Th2 Cells
IL-4, IL-5, IL-10
42
HLA - A3
Hemochromatosis
43
HLA - B27
Ankylosing spondylitis Psoriasis Arthritis of IBD Reactive arthritis
44
HLA - DQ2/DQ8
Celiac
45
HLA - DR2
Multiple sclerosis Hay fever SLE Goodpastures
46
HLA - DR3
DM T1, SLE, Graves, hashimotos
47
HLA - DR4
DM T1, Rheumatoid arthritis
48
HLA - DR5
Pernicious anemia, Hashimotos
49
Regulatory T-cell markers
CD3, CD4, CD25, FOXP3
50
C-reactive protein
Opsinin; fixes compliment
51
IL-6
stimulates acute phase reactants
52
IL-5
Class switching to IgA; growth of eosinophils
53
IL-4
CLass switching to IgE and IgG
54
Hematopoetic stem cell marker
CD34
55
Chediak-hegashi
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Ryan's shit list - Step 1 (27 decks)

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