S2 Glucocorticoids & Cyclosporine Flashcards Preview

Pharmacology > S2 Glucocorticoids & Cyclosporine > Flashcards

Flashcards in S2 Glucocorticoids & Cyclosporine Deck (14):
1

Glucocorticoids

Biological molecule = cortisol
Some molecules may bind to mineralocorticoid receptors

2

Mineralocorticoids

Biological molecule = aldosterone
Some molecules may bind to glucocorticoid receptors

3

Mifepristone

RU-486
Glucocorticoid antagonist
Also acts as a progesterone antagonist

4

Prednisolone

Intermediate potency and duration
Similar to Triamcinolone
Much higher oral bio-availability
Best choice for cats

5

Prednisone

Lower GI absorption
Inactive form
Requires hepatic metabolism
Conversion to active prednisolone

6

Cortisone

Inactive form
Requires hepatic metabolism
Conversion to active cortisol (hydrocortisone)
Weakest corticosteroid drug

7

Hydrocortisone (cortisol)

Low potency and short duration
Some mineralocorticoid activity

8

Triamcinolone

Intermediate potency and duration
Similar to prednisolone

9

Dexamethasone

Glucocorticoid full agonist
High potency and long duration (> 48 hrs)

10

Cyclosporin

Immunosupressive drug
Calcineurin inhibitor = T-cell suppressant
No effect on immunoglobulins
Similar but weaker than Tacrolimus

11

Tacrolimus

Immunosupressive drug
Calcineurin inhibitor = T-cell suppressant
No effect on immunoglobulins
500X more potent than Cyclosporin!
Dermatological use only

12

Cortisol, dexamethasone, & corticosterone

Glucocorticoid full agonists

13

Deoxycorticosterone

Glucocorticoid partial agonist

14

Effects of glucocorticoids

1. Inhibition of eicosanoids
2. Reduction in proinflammatory cytokines
3. Decreased IgE induced release of histamine and leukotrienes
4. Decreased leukocyte adhesion molecules
5. Inhibition of growth factors
a. Inhibits wound healing= negative effect
PALLIATIVE DRUGS ONLY!
= does not treat underlying cause