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Flashcards in Samplex 2016 Deck (22)
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1

Which of the ff is a receptor connected to an ion channel/ligand-gated ion channel?

a. D1
b. 5HT1
c. 5HT3
d. D2

C

2

What is a characteristic of a molecule that can easily enter?

a. Small molecule
b. Protein bound
c. Large
d. Hydrophilic

A

3

Delimited in their anatomic distribution

a. Hierarchal systems
b. Diffuse systems

A

4

Conduction velocity is 0.5 m/s

a. Hierarchal systems
b. Diffuse systems

B

5

Pathway from the reticular formation and locus ceruleus would best fit this system

a. Hierarchal systems
b. Diffuse systems

B

6

Arterioles

a. predominant cholinergic
b. predominant is adrenergic

B

7

Sweat glands to the palms/soles

a. predominant cholinergic
b. predominant is adrenergic

B

8

Which of the following are characteristics of voltage gated Na channels?

a. Found on initial segment of dendrites
b. Modulate rate of neuronal discharge
c. Mediates signals from cell body to the nerve terminal
d. Action is of a slower time scale

C

9

Characteristics of membrane delimited metabotropic receptors?

a. g protein directly activates ion channel
b. activation of presynaptic calcium channels
c. inhibition of postsynaptic potassium channel
d. AOTA

A

10

Sympathetic activation leads to

a. Increased alertness
b. Bladder contraction
c. ↑ peristalsis

A

11

Postsynaptic activation of Alpha 1 receptor will lead to:

a. Cutaneous vasodilation
b. Lipolysis
c. Nasal Decongestion
d. Uterine relaxation

C

12

A adrenergic agonist which can dilate splanchnic and renal vasculature and can increase contraction and peripheral vascular resistance

a. Albuterol
b. Dobutamine
c. Dopamine
d. Isoproterenol

C

13

An adolescent brought to the ER presenting with aggressive behaviour, tremor, anxiety, paranoid state, hypertension, and tachycardia was diagnosed to have metamphetamine abuse. Which of the ff. is the action of amphetamine?

a. It binds directly to Alpha 1 and Beta 1 receptors
b. It displaces NE from vesicles
c. It enhances MAO activity
d. It promotes exocytotic release of NE

B

14

beta 1 selective with half life 10 to 15 mins

a. Carvedilol
b. Propanolol
c. Pindolol
d. Esmolol
e. NOTA

D

15

non-selective beta blocker

a. Carvedilol
b. Propanolol
c. Pindolol
d. Esmolol
e. NOTA

B

16

non-selective beta and alpha antagonist

a. Carvedilol
b. Propanolol
c. Pindolol
d. Esmolol
e. NOTA

A

17

non-selective beta with partial agonist activity

a. Carvedilol
b. Propanolol
c. Pindolol
d. Esmolol
e. NOTA

C

18

Incorrect association between histamine and its distribution in organs.

a. H1 – extravascular smooth muscle
b. H2 – gastric parietal cells
c. H3 – CNS
d. H4 - myocardial cells

D

19

Histamine-1 antagonists are useful in the treatment of itching and edema associated with allergies. Which of the following is not an H1 antagonist?

a. chlorphenamine
b. fexofenadine
c. cimetidine
d. loratidine

C

20

Incorrect match between the 5HT receptor antagonist / agonist drugs with their clinical use

a. 5HT3 Antagonist / ondansetron – nausea, vomiting
b. 5HT4 agonist / Cisapride – anxiety/depression
c. 5HT 1D agonist / Sumatripan – migraine
d. 5HT2A Antagonist / Ketaneserin – hypertension

A

21

Incorrect about Kallikrein-kininogen-kinin/KKK system:

a. Bradykinin causes vasodilation and cough
b. High molecular weight kinninogen is important in activation of intrinsic clotting pathway
c. Aprotinin which inhibits kallikrein  reverse bleeding due to heparin
d. Tissue damage cannot activate KKK

D

22

Not a function of 5ht

a. Regulation of GI motility and peristalsis
b. Bronchodilation
c. Central chemical transmitter for tryptaminergic neurons of the brain
d. Precursor of melatonin

B