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Flashcards in Samplex 2017 Deck (32)
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1

Which is true regarding drug absorption in children?

A. Intestinal motility in children is slower than in newborn
B. Delayed gastric emptying time in children results to less absorption
C. Suspension is better absorbed than liquid dosage

B

2

Lipophilic drugs have low Vd in premature babies because:

A. Kidney immaturity
B. Low amount of liver enzymes
C. Low amount of body fat
D. Little fat tissues

D

3

Factor than can facilitate the passage of drugs from blood-organ barriers:

A. Complete anatomic development of barrier
B. Decreased permeability of the membrane
C. Complete myelinisation in the brain
D. Acidosis and hypoglycaemia

D

4

Benefit of pharmacogenetics:

A. Better vaccines
B. Better dosage regimens
C. Decreased cost of health care
D. A or B
E. AOTA

E

5

The ff. genetic polymorphisms were discovered before the completion of the human genome project in 2003:

A. Primaquine-induced haemolytic anemia secondary to G6PD deficiency in patients treated for malaria
B. Slow acetylators phenotype in Isoniazid patients
C. Succinylcholine sensitivity secondary to pseudocholinesterase
D. A and B only
E. AOTA

E

6

The following is not considered an adverse drug reaction

A. Bradycardia from methyldopa
B. No clinical effect on BP reading from generic nifedipine
C. Bleeding from warfarin
D. Agranulocytosis from propylthiouracil

B

7

Dose-related type A pharmacokinetic variation causing adverse drug reaction can be due to one of
the following:

A. Change in formulation
B. Prolonged apnea on succinylcholine
C. Expired drugs
D. Presence of pyrogens in parenteral meds

A

8

Hyperkalemia potentiates the effect of the following:

A. Lignocaine
B. Quinidine
C. Digitalis
D. Amphetamine

C

9

Peripheral neuropathy with the use of Isoniazid is more commonly seen among:

A. Slow acetylators
B. Rapid acetylators
C. Intermediate acetylators
D. Rapid Hydroxylators

A

10

Hemolytic anemia allergy due to Penicillin. What type is this according to Gel and Coombs classification?

A. Type I (IgE)
B. Type II (Cytotoxicity)
C. T-cell meditated
D. Type IV (Cell-mediated)

B

11

A dermatologic manifestation caused by oral contraceptives

A. Urticaria
B. Liver peliosis
C. Melasma
D. Morbiliform rash

D

12

Which is true regarding nature of toxic action of a drug

A. Toxic effect is an exaggeration of therapeutic action
B. Effect of acute exposure is same as chronic
C. Toxicant can exert several mechanisms for toxic effect
D. Sites with highest concentration of substance manifest symptoms

C

13

2nd stage of development of toxicity:
A. Delivery
B. Cell injury
C. interaction with target
D. Dysrepair

C

14

The factors that affect/s toxicity:

A. Duration of exposure
B. Chemical properties of toxicant
C. Individual factors
D. AOTA

D

15

Pharmacokinetic drug interaction except:

A. IV incompatibilities
B. Absorption of drug
C. ↑ protein binding of one displaces the other

A

16

Presynaptic fibers come from the craniosacral outflow.

A. If statement applies to sympathetic NS only
B. If statement applies to parasympathetic NS only
C. If statement applies to both
D. If statement applies to neither

B

17

Preganglionic fibers terminate in the ganglion in wall of target organs

A. If statement applies to sympathetic NS only
B. If statement applies to parasympathetic NS only
C. If statement applies to both
D. If statement applies to neither

B

18

It is not under direct conscious control

A. If statement applies to sympathetic NS only
B. If statement applies to parasympathetic NS only
C. If statement applies to both
D. If statement applies to neither

D

19

True about cholinergic transmission except:

A. An action terminated by diff. and uptake
B. Hemicholinum – Entry of choline into nerve terminal
C. Reserpine– Transport of NT into vesicle
D. Fusion with PM is Ca2+-dependent
E. Botox – Fusion of vesicle with PM

A

20

Which of the following serotonin receptors is ligand-gated?

A. 5HT 1A
B. 5HT 2C
C. 5HT 3
D. 5HT 4

C

21

Characteristic of molecule that will cross the blood-brain barrier:

A. Bound to plasma protein
B. Large molecule
C. Lipid soluble
D. Hydrophilic

C

22

What is a characteristic of membrane delimited metabotropic receptors?

A. G-something directly acts on ion channels
B. Activates presynaptic Ca channels
C. Inhibits postsynaptic K channels
D. Predominates in hierarchial pathways

A

23

Which of the following neuromuscular blocker has the shortest duration?

A. Pancuronium
B. Tubocurarine
C. Mivacurium
D. Succinylcholine

D

24

Non-depolarizing blocking drugs do not produce significant autonomic effects.

A. True
B. False

B

25

Sympathetic activation results to the following:

A. Vasodilation
B. Pupillary constriction
C. Bladder contraction
D. Perspiration

D

26

What is the effect of amphetamine?

A. Promotes release of NT
B. Blocks receptors
C. Blocks MAO
D. AOTA

D

27

A patient rushed to the ER for bronchospasm secondary to anaphylactic shock was given IM epinephrine and NE. The following are expected effects:

A. Bronchodilation
B. Vasodilation
C. Decreased cardiac contractility
D. AOTA

A

28

Drug which inhibits the Ca2+-dependent release of norepinephrine:

A. Amphetamine
B. Cocaine
C. Guanethidine
D. Reserpin

C

29

Which is not an H1 antagonist?

A. Chlorphenhydramine
B. Cimetidine
C. Diphenhydramine
D. Loratadine

B

30

Not a known function of leukotriene?

A. Contract smooth muscle
B. Secrete mucus
C. Inhibits transendothelial migration of neutrophils

C