Schizophrenia

Question 1

What are structural findings in the brain?

Answer 1

Enlargement of the third and lateral ventricles
Reductions in total brain volume and grey matter volume
Regional reductions in the amygdala, parahippocampal gyrus and temporal lobes
Reduced asymmetry - planum temporale

Question 2

What are functional changes seen in schizophrenia

Answer 2

Decreased activation of prefrontal cortex
Increased activation of temporal regions during hallucinations