Flashcards in Screening guidelines for newborns at risk for low blood glucose Deck (14):
What are symptoms of neonatal hypoglycemia?
1. Jitteriness or tremor
5. Intermittent apneic spells or tachypnea
6. Weak or high-pitched cry
9. Difficulty in feeding
10. Eye rolling
12. Sudden pallor
14. Cardiac arrest
15. Cardiac failure
What are three approaches to defining a safe range for blood glucose?
1. Using normative ranges
2. Using the presence or absence of sequelae
3. Using prospective clinical trials to determine whether benefit of intervention outweighs the short-term and long-term risks
What normative ranges have been noted in breastfed, term, appropriate for GA babies?
1.8 @ 1h of life, then >2.0 x 72h
12-14% BA <2.6 in the 1st 72h
When infants usually symptomatic?
but some report <1.6
Who is at risk for neonatal hypoglycemia?
1. SGA (<10th percentile)
2. LGA (>90th percentile)
4. Preterm infants
5. Perinatal asphyxia
Why does impaired gluconeogenesis occur, resulting in neonatal hypoglycemia?
1. Excess insulin production
2. Altered counter-regulatory hormone production
3. Inadequate substrate supply
When should at-risk infants be screened?
1. Screening should be initiated in at-risk babies at 2h of age
2. Continue screening until the period of risk is considered over
3. LGA and IDM can stop screening if BS >2.6 x 12h
4. Preterm and SGA can stop screening if BS >2.6 x 36h
5. Symptomatic infants should have blood glucose assessment without delay
How should screening for neonatal hypoglycemia be performed?
Rapid laboratory testing should be available to verify POC glucose checks
When does symptomatic hypoglycemia require intervention?
When does asymptomatic hypoglycemia require intervention?
1. Asymptomatic, at-risk babies should receive at least one effective feed before a blood glucose check at 2 h of age and should be encouraged to feed regularly thereafter. At-risk babies who have a blood glucose of less than 1.8 mmol/L at 2 h of age despite one feed (breastfeed or approximately 5 mL/kg to 10 mL/kg of formula or glucose water), or less than 2.0 mmol/L after subsequent feeding, should receive an intravenous dextrose infusion.
2. At-risk babies who repeatedly have blood glucose levels of less than 2.6 mmol/L despite subsequent feeding should also be considered for intravenous therapy.
What interventions should be offered when neonatal asymptomatic hypoglycemia is suspected?
1. Offer feeding intervention and re-check level in 60min to ensure response
2. If increased enteral caloric intake is ineffective D10W @ TFI 80 (GIR 5.5)
3. If BS <1.8 confirm response within 30min
4. 2mL/kg IV D10W bolus at start of an infusion more rapidly achieves steady state level, benefit in asymptomatic babies is uncertain
5. Repeated mini-boluses without an increase in the infusion rate are not recommended
What interventions should be offered when neonatal symptomatic hypoglycemia is suspected?
1. Immediate D10W IV @ TFI 80 (GIR 5.5) and confirm response in 30min
2. Target BS >2.6
3. Change from D10W to D12W OR TFI 80 to 100 will increase GIR 25%
4. If fails, increase from D12.5W @ TFI 100 to 120 (GIR 8.7 to 10.4)
5. If D12.5W @ TFI 120 fails to keep BS >2.6 consider further investigations, specialist referral and/or pharmacological intervention (i.e. glucagon)
6. Investigations should be aimed to identify endocrine pathology (i.e. hyperinsulinism) or IEM
7. Glucagon IV bolus (0.1-0.3mg/kg) or infusion (10-20ug/kg/h) raise BS
8. Other therapeutic options incld: hydrocortisone, diazoxide, and octreotide
9. May continue breastfeeding but oral and IV intake should not be >100mL/kg/day
10. Wean IVF when BS levels stable x 12h
How frequently should asymptomatic, at-risk infants be screened?
Before feeds x 24h, then 2-3 times on day two