Flashcards in Secondary Lymphoid Organs Deck (76)
Where do B cells and T cells originate?
Where do B cells mature?
Where do T cells migrate to mature?
What are the secondary lymphoid organs?
Lymph nodes (500-600 in the body), spleen, and mucosal-associated lymphoid tissue (MALT)
Where does the recognition phase of the adaptive immune response occur?
In the secondary lymphoid organs (lymph nodes usually)
How do secondary lymphoid organs help lymphocytes survive and continue to recirculate even when they don't find their cognate antigen?
By providing them with sustaining signals
Are lymphoid follicles present among all secondary lymphoid organs?
Yes, very common
What type of lymphoid follicle involves a loose network of follicular dendritic cells rich in naive and memory B cells?
Which type of lymphoid follicle occurs after antigen stimulation and includes a germinal center specific for replication and differentiation?
What is the difference between the antigen presenting dendritic cells and the follicular dendritic cells?
Follicular dendritic cells are stationary and remain in the lymph node unlike the traveling antigen presenting dendritic cells
Do the B cells of a primary lymphoid follicle "island" likely have different BCRs or are they likely to all be the same?
They are most likely all different which makes the proliferation aspect critical to increase amount of B cells with the same BCRs
What is the normal function of follicular dendritic cells?
Catch and display opsonized antigen to B cells with high affinity receptors
Follicular dendritic cells may be related to what other kind of cell?
Are follicular dendritic cells a type of white blood cell?
What conditions can result in ectopic follicular dendritic cells?
Autoimmune and inflammatory conditions
Are follicular dendritic cells a part of the parenchymal or stromal cells of the secondary lymphoid organ?
Follicular dendritic cells have receptors that bind antigens to what region of antibodies?
Fc (constant tail region)
Can follicular dendritic cells bind to complement proteins?
What is the purpose of the follicular dendritic cells attaching to and holding opsonized antigens?
BCRs cluster and crosslinks more easily enabling more activation
Germinal centers are associated with which type of lymphoid follicle?
Are all the B cells in the germinal center identical clones?
The formation of germinal centers is associated with what appearance of lymph nodes?
Visibly swollen lymph nodes
The many proliferating B cells involved with a germinal center gives off what microscopic appearance?
What happens to the lower affinity BCR B cells of the germinal centers?
They die by apoptosis and are eaten by macrophages
Where does class switching of antibodies occur?
In the "dark zone" of the germinal centers
In those with T cell deficiency, what is the only antibody class that can be created by B cells?
Peyer's patches and the appendix are associated with what kind of lymphoid tissue?
GALT (gut-associated lymphoid tissue)
The tonsils and adenoids are associated with what type of lymphoid tissue?
NALT (nasal-associated lymphoid tissue)
Which type of lymphoid tissue is associated with the respiratory system?
BALT (bronchial-associated lymphoid tissue)