Sedative Hypnotic Drug Flashcards Preview

Pharmacology 2 > Sedative Hypnotic Drug > Flashcards

Flashcards in Sedative Hypnotic Drug Deck (36):
1

Major excitatory neurotransmitters

Glutamic acid
Aspartic acid

2

MOA of benzodiazepines

Binds GABA-alpha receptor subunits to increase FREQUENCY of chloride channel opening
Membrane hyperpolarization

3

Short acting benzodiazepines

Midazolam
Brotizolam
Triazolam
Oxazepam
Etizolam

4

Intermediate acting benzodiazepines

Lorazepam
Alprazolam
Clonazepam
Estazolam
Lormetazepam
Nitrazepam
Temazepam

5

Long acting benzodiazepines

Diazepam
Flunetrazepam
Chlordiazepoxide
Chlorazepate

6

Benzodiazepine with longest half life

Chlordiazepoxide. 36-200 hours

7

Date rape drugs

Alcohol (most common)
Flunitrazepam (rohypnol)
Gamma-hydroxybutyrate

8

Anticonvulsant maintenance

Clonazepam

9

Status epilepticus

Lorazepam
Diazepam

10

Skeletal muscle relaxation

Diazepam

11

Panic disorders, phobias

Alprazolam
Clonazepam

12

Insomnia

Estazolam
Flurazepam
Triazolam

13

Anesthesia induction

Midazolam
Diazepam

14

Bipolar disorder

Clonazepam

15

Alcohol withdrawal

Chlordiazepoxide
Diazepam

16

Tx for benzodiazepine overdose

Flumazenil
Activated charcoal is useless

17

Benzodiazepine antagonist

Flumazenil

18

Ultra Short acting barbiturates

Thiopental
Methohexital
Thiamylal

19

Short and intermediate acting barbiturates

Pentobarbital
Secobarbital
Amobarbital

20

Long acting barbiturates

Phenobarbital
Mephobarbital
Primidone

21

MOA of barbiturates

Bind to GABA-alpha receptor sites, increases DURATION of chloride channel opening

22

Barbiturate used in treatment of Gilbert's syndrome (hyperbilirubenemias)

Phenobarbital

23

MOA and use of Zolpidem

Bind selectively to a subgroup of GABA-alpha receptors, use for insomnia only
Similar drugs are Zaleplon and Eszopiclone

24

Drug for generalized anxiety disorder

Buspirone

25

Major inhibitory neurotransmitters

GABA
Glycine

26

Capacity of alcohol metabolism per hour

7-10 g

27

Responsible for metabolism of ethanol at blood levels higher than 100 mg/dl

Microsomal ethanol oxidizing system

28

Inhibits aldehyde dehydrogenase

Disulfiram
Metronidazole
Oral hypoglycemics
Some cephalosporins

29

Blood alcohol concentration with impairment of driving ability

60-80 mg/dl, 60 is legally drunk in PH

30

Blood alcohol concentration producing coma

300-400
Death at >500 mg/dl

31

Wernicke-Korsakoff syndrome

Ataxia
Confusion
Ophthalmoplegia-paralysis of EOM
Thiamine administration is used to treat

32

Delirium tremens

HAD 48
Hallucinations
Autonomic instability
Delirium
48-72 hours post-discontinuation

33

DOC for alcohol withdrawal syndrome

Long acting benzodiazepines
Diazepam
Chlordiazepoxide
Short acting is preferred in patients with compromised liver function

34

Used in treatment of alcoholism

Naltrexone
Acamprosate
Disulfiram

35

Treatment of methanol poisoning

Ethanol
Fomepizole

36

Inhibitor of alcohol dehydrogenase

Fomepizole
Used in methanol and ethylene glycol poisoning