Sedative-Hypnotic Drugs Flashcards Preview

P Pha T > Sedative-Hypnotic Drugs > Flashcards

Flashcards in Sedative-Hypnotic Drugs Deck (16):
1

GABA Receptor Effects
Benzodiazepine - affects __________
Barbiturates - affects ___________

Frequency (FREnzodiazepine)
Duration (BarbiDURATes)

2

Benzodiazepines
- lower risk of medullary depression than barbiturates
- decreased ____ sleep

REM

3

Short-acting benzodiazepine
For anesthesia induction, preoperative sedation
SE: anterograde amnesia, unwanted daytime sedation, rebound insomnia/anxiety

Midazolam
SimD: Brotizolam, triazolam, oxazepam, etizolam

4

Intermediate-acting benzodiazepine
For seizure disorders; tranquilizer
SE: anterograde amnesia, unwanted daytime sedation

Lorazepam
SimD: alprazolam, estazolam, clonazepam, lormetazepam, nitrazepam, temazepam

5

Long-acting benzodiazepine
Used as a date-rape drug

Flunitrazepam (Rohypnol)
SimD: DIAZEPAM, flurazepam, wuazepam, chlorazepate, chlordiazepoxide

Other date-rape drugs:
Alcohol (most common)
Gamma-hydroxybutyrate

6

Inhibitor of glycine, an inhibitory NT

Stricnine

7

Benzodiazepine with longest half-life

Chlordiazepoxide

8

CLINICAL USE -- Preferred BENZODIAZEPINE
Anticonvulsant maintenance -
Status epilepticus -
Skeletal muscle relaxation (e.g. CP) -
Panic disorders, phobias -
Insomnia -
Anesthesia induction -
Bipolar disorder -
Alcohol withdrawal -

CLINICAL USE -- Preferred BENZODIAZEPINE
Anticonvulsant maintenance - clonazepam
Status epilepticus - lorazepam, diazepam
Skeletal muscle relaxation (e.g. CP) - diazepam
Panic disorders, phobias - alprazolam, clonazepam
Insomnia - estazolam, flurazepam, triazolam
Anesthesia induction - midazolam, diazepam
Bipolar disorder - clonazepam
Alcohol withdrawal - chlordiazepoxide, diazepam

9

Antidote for benzodiazepine overdose
Antagonist on GABA-A receptors

Flumazenil

10

Barbiturates
- bind to _______ receptor site (distinct from benzodiazepines)
- increases duration of _________ channel opening
- SE: acute intermittent porphyria (deficient enzyme: HMB synthase)
- Medullary depression is _______-dependent in barbiturates

GABA-A
chloride
dose

11

Ultra-short-acting barbiturate

Thiopental
(TAYO agad)

12

Short- to intermediate-acting barbiturate

Pentobarbital
SimD: secobarbital, amobarbital, butalbital,butabarbital, talbutal, aprobarbital

13

Long-acting barbiturate

Phenobarbital
SimD: mephobarbital, primidone

14

Most catastrophic symptom of sedative-hypnotic withdrawal

Rebound suicide

15

Imidazopyridine
For insomnia only
Effects reversed with Flumazenil

Zoldipem
SimD: zaleplon, eszopiclone

(Think: for zzzzzzzzzzleep disorders)

16

Anxiolytic drug
Partial agonist at 5-HT1A receptors and possibly D2 receptors
For generalized anxiety disorder

Buspirone
(THink: Buspirone for busy people i.e. always anxious)

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