Selexipag (Uptravi) Flashcards Preview

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Flashcards in Selexipag (Uptravi) Deck (14)
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1

What is the pharmacologic class of selexipag? (Lexi)

Prostacyclin IP receptor agonist

2

What is the initial dose of selexipag? (Lexi)

200 mcg twice daily

3

How is selexipag typically titrated? (Lexi)

Increase by 200 mcg twice daily, usually at weekly intervals

4

What is the maximum dose of selexipag? (Lexi)

1600 mcg twice daily

5

What are renal impairment considerations with selexipag? (Lexi)

1. eGFR > 15 no dosage adjustment necessary
2. eGFR < 15 not studied

6

What are hepatic impairment considerations with selexipag? (Lexi)

Avoid in severe hepatic impairment (Child-Pugh class C)

7

What are the labeled indications for selexipag? (Lexi)

PAH WHO group I

8

What is a consideration for oral administration of selexipag? (Lexi)

With or without food, but tolerability may be improved with food

9

What drug would be contraindicated with selexipag secondary to strong CYP2C8 inhibition? (Lexi)

Gemfibrozil

10

What are adverse reactions with frequency >10% associated with selexipag use? (Lexi)

1. Cardiovascular = Flushing (12%)
2. CNS = Headache (65%)
3. Dermatologic = Skin rash (11%)
4. GI = Diarrhea (42%), Nausea (33%), Vomiting (18%)
5. Neuromuscular / Skeletal = Jaw pain (25%), limb pain (17%), myalgia (16%), arthralgia (11%)

11

Where is prostacyclin produced? (Lexi)

Produced in the endothelial cells

12

What are actions of prostacyclin? (Lexi)

1. Vasodilation
2. Inhibits platelet aggregation

13

What is the bioavailability of selexipag? (Lexi)

49%

14

What is the half-life of selexipag? (Lexi)

~ 12 hours
1. Terminal (1-3 hours)
2. Active metabolite (6-13 hours)