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Flashcards in Self Study 1 Deck (26):
1

what is the annual incidence of colorectal CA in canada?

20800 cases

2

how many deaths are dt colorectal CA in can

8700

3

what is to be said about colorectal CA rates in can

they are decreasing

4

what is the Et of colorectal CA

idiopathic

5

what is the relationship between colorectal CA and age

inc incidence with age, 90% cases occur in pts >50yo

6

what family hx puts you at inc risk for colorectal CA

CA, ulcerative colitis, chrons disease, adenomatous polyps of the colon

7

what diet mods put you at risk for colorectal CA

inc fat and refined sugar intake

8

why does fat ingestion put you at risk for colorectal CA

inc fat -> inc bile sec -> bile may be converted to carcinogens by GI flora

9

why does sugar ingestion put you at risk for colorectal CA

increases prolif of GI flora

10

what diet mods can prevent colorectal CA

fiber intake, vit, A C E intake

11

why does fibre help prevent colorectal CA

inc stool bulk there fore -> dec accum of GI flora

12

why do vit's A C and E prevent colorectal CA

they are free radical scavengers, dec free radicals in colon

13

why may aspirin protect the GI from colorectal CA

dt its influence in prostaglandin synth which may involve cell signalling that affects tumor growth

14

what does aspirin inhibt in colorectal CA

ez req to create prostaglandins

15

mnfts of colorectal CA

bleeding, change in bowel habits, diarhea, constipation, urgency

16

stage 1 colorectal CA

limited to invasion of mucosa + submucosa of colon
90-100% chance 5yr survival rate

17

stage 2 colorectal CA

infiltrates into but not throughout muscularis externa, 5yr survival of 80%

18

stage 3 colorectal CA

invasion of serosal layer + regional lymph node involvement, 5yr survival of 30%

19

stage 4 colorectal CA

metastic tumors penetrate serosa and adjacent organs
poor prognosis

20

5 screening tests used for colorectal CA

digital rectal exam
FOB
x ray w/ barium enema
sigmoidoscopy
colonoscopy

21

digital rectal exam in colorectal CA

detecting neoplasms in rectum

22

FOB in colorectal CA

recomened to have done every 1-2 yrs if >50yo

23

what happens if FOB test is positive in colorectal CA

x ray with barium enema for imaging
sigmoidoscopy
colonoscopy

24

sigmoidoscopy colorectal CA

exam of rectum and sigmoid colon with hollow lighted tube. detects 40% of CA and polyps

25

colonoscopy colorectal CA

exam of entire bowel. screening, biopsy, polyp removal

26

tx for colorectal CA

sx and removal
MAYBE pre op radiation in early cases with inc 5 yr survival rate