Serotonin Receptors Flashcards Preview

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Flashcards in Serotonin Receptors Deck (26):
1

5-HT 1A locations? (3)

- Cortex, hypothalamus
- Raphe nuclei

2

5-HT 1A effects on cortex, hypothalamus, and raphe nuclei?

- Mood, cognitive function, neuroendocrine function
- Raphe: inhibits 5-HT release

3

5-HT 1D locations? (2)

- Cerebral vascular smooth m.
- Nerve terminal

4

5-HT 1D effects on cerebral vascular smooth m. and nerve terminals?

- Vasoconstriction
- Inhibits NT release from nerve terminals (e.g. nociceptive and inflammatory mediators in migraines)

5

5-HT 2A/2C locations? (2)

- Striatum
- Frontal cortex

6

5-HT 2A/2C effects on the striatum and frontal cortex?

Hallucinations via inhibiting DA release

7

5-HT 3 locations? (3)

- Enteric chromaffin cells
- Area postrema
- Emetic center

8

5-HT 3 effects on the enteric chromaffin cells, area postrema, and emetic center?

Gut motility, N/V

9

5-HT 4 location? (1)

Myenteric plexus (ENS)

10

5-HT 4 effect on myenteric plexus?

Gut motility

11

5-HT transporter location?

5-HT nerve terminals

12

5-HT transporter effect on 5-HT nerve terminals?

Removal of 5-HT from synapse

13

What 5-HT receptor does buspirone effect, + specific type of agonism/antagonism?
Associated clinical disorders?

5-HT 1A partial agonist
- Anxiety, depression

14

What 5-HT receptor does sumatriptan effect, + specific type of agonism/antagonism?
Associated clinical disorder?

5-HT 1D agonist
- Migraine

15

What 5-HT receptor does trazadone effect, + specific type of agonism/antagonism?
Associated clinical disorders?

What medication is it contraindicated with?

SARI; 5-HT 2A/2C antagonist + SSRI (5-HT xporter inhibitor)
- Depression, schizophrenia (contraindicated w/MAO inhibitors)

16

What 5-HT receptor does ondansetron effect, + specific type of agonism/antagonism?
Associated clinical disorder?

5-HT 3 antagonist
- Chemo-induced emesis

17

What 5-HT receptor does mosapride (UK) effect, + specific type of agonism/antagonism?
Associated clinical disorders?
1 serious side-effect? (think)

5-HT 4 agonist
- GI disorders
- SE: arrhythmia (lengthens QT)

18

What 5-HT receptor does fluoxetine/sertraline effect, + specific type of agonism/antagonism?
Associated clinical disorders?

W/what medication are they contraindicated?

5-HT transporter inhibitor
- Depression, panic disorder, OCD, PTSD, social phobia

Contraindicated w/MAO inhibitors (Serotonin syndrome)

19

What 5-HT receptor does risperidone effect, + specific type of agonism/antagonism?
Associated clinical disorders?
*Which 2 DA pw's does it affect and how?

2nd gen anti-psychotic: 5-HT 2A + D 2/3 antagonist
- Schizophrenia w/psychosis
* Suppresses DA release in mesolimbic pw (reduce psychosis via D 2/3), increases DA release in mesocortical pw (reduce hallucinations via 5-HT 2A)

20

What receptor does L-DOPA effect, + specific type of agonism/antagonism?
Associated clinical disorder?

Serious side effects?

D 1/2 receptor agonist (increases DA in nigrostriatal pw)
- PD

SE: Arrhythmia, dyskinesia

21

What enzyme does carbidopa effect? Positively or negatively?
Associated clinical disorder?

Targets AADC (makes DA from L-DOPA) in peripheral tissues
- PD

22

What receptor does bromocriptine effect, + specific type of agonism/antagonism?
Associated clinical disorder?

D 2/3 receptor agonist
- PD

23

What receptor does selegiline effect, + specific type of agonism/antagonism?
Associated clinical disorder?

Serious side effects?
Contraindicated w/what medication?

MAO-B selective antagonist
- PD (early)

SE: Hypotension, hypertensive crisis
- Sympathomimetics

24

What enzyme does tolcapone effect? Positively or negatively?
Associated clinical disorder?

Contraindicated w/what dz?

Inhibits COMT
- PD (advanced)

Liver failure

25

What receptor does haloperidol effect, + specific type of agonism/antagonism?
Associated clinical disorder?

D2 antagonist
- Psychosis

26

What receptor does metaclopramide effect, + specific type of agonism/antagonism?
Associated clinical disorder?

Major side effects?

D2 antagonist + 5-HT 4 agonist properties
- Nausea

SE: akathisia, focal dystonia