Session 1: Biological Signalling Molecules Flashcards Preview

Sem 1: Pharamacology and Physiology > Session 1: Biological Signalling Molecules > Flashcards

Flashcards in Session 1: Biological Signalling Molecules Deck (16):
1

What are the 3 main extracellular signalling groups?

Endocrine
Paracrine
Autocrine

2

TRUE OR FALSE: endocrine signalling molecules usually act over long distances throughout the whole body.

TRUE

3

Name 3 categories of endocrine signalling molecules.

1. Amine hormone
2. Peptide hormone/ protein hormone
3. Steroid hormone

4

Where is the receptor location for amine/protein endocrine hormones?

Plasma membrane

5

Where is the receptor located for steroid hormones?

Cytosolic or nuclear

6

Define paracrine signalling

From cell to cell (or cells within nearby volume)

7

Define autocrine signalling

Cells respond to signalling molecules preocupes and released by themselves

8

Name 4 signalling molecule targets.

1. Receptors
2. Ion channels
3. Transporters
4. Enzymes

9

Name 4 signalling molecule receptors.

1. Kinase linked receptors
2. Ion channels (ligand gated)
3. Nuclear /intracellular
4. G-protein coupled receptors

10

How do kinase linked receptors work?

Act via phosphorylation of specific groups, which sets into motion a signalling cascade leading to gene transcription

11

How do Ion gated ligand channels work?

Voltage change occurs which results in an action potential

12

How do nuclear/ intracellular receptors work?

Lipid soluble steroid signalling molecule required. Complex migrates to the nucleus where it binds to a transcription factor.

13

How do GPCR receptors work?

Three major types: Gs, Gi, Gq which activate different intracellular signalling routes

14

What is the function of ion channels?

Selectively allow ion current to flow across the plasma membrane down its concentration gradient.

15

What do transporters do?

Use ATP or a pre-existing ion gradient to transport highly polar molecules across the membrane.

16

Give an example of a transporter.

Na+/K+ ATPase