Session 3 and 4 Flashcards

(52 cards)

1
Q

What is the pre embryonic period?

A

describe what happens in this period

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2
Q

Describe the process of fertilisation

A

from oocyte to implantation

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3
Q

Describe what happens in week 1 (how the blastocyst is formed)

A
cleavage
zona pellucida
morula
blastocyst- what does this contain?
totipotent and pluripotent 
hatching
implantation
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4
Q

How do assisted reproductive techniques work?

A

in vitro
4 or 8 cell stage
morula to uterus
PGD

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5
Q

What happens in week 2?

A

differentiation
syncytiotrophoblast
cytotrophoblast
bilaminar disk (what is this?)

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6
Q

What is the fibrin plug?

A

blood clot

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7
Q

What happens by the end of week 2?

A
implanted
embryo + its two cavities
suspended 
within 
supporting sac
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8
Q

Describe the process of implantation

A

interstitial
blood flow
chorionic villus

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9
Q

What are the conditions linked to implantation defects? Describe them

A

IUGR
pre eclampsia
ectopic pregnancy (Fallopian tube implant)
placenta praevia (lower uterine segment implantation)

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10
Q

Describe the embryonic pole and the abembryonic pole

A

syncytiotrophoblast

primitive yolk sac

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11
Q

What happens in the latter half of the second week?

A
primitive yolk sac pushed away
reticulum layer
maternal sinusoids
uteroplacental circulation
secondary yolk sac
extraembryonic mesoderm 
connecting stalk
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12
Q

Define the different cavities (blastocyst cavity, amniotic sac, primitive yolk sac, secondary yolk sac, extraembryonic coelom)

A
first cavity
spaces within the epiblast
hypoblast lining blastocyst cavity
definitive yolk sac
chorionic cavity
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13
Q

Describe the embryonic period

A

3 to 8
change
malformation

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14
Q

What is teratogenesis and when is it possible?

A

the process by which congenital malformations are produced in an embryo or fetus
pre embryonic
embryonic
fetal

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15
Q

What are the key events?

A
fertilisation and implantation
gastrulation
neurulation 
segmentation
folding
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16
Q

What is the primitive streak?

A

epiblast
dorsal surface

leads to the migration and invagination of epiblast cells

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17
Q

Describe the process of invagination and migration

A
epiblast cells
intracellular junctions
embryonic disk
hypoblast 
third layer
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18
Q

What is the trilaminar disk?

A

ectoderm
mesoderm
endoderm
epiblast layer

remove ectoderm layer
endoderm two patches
mouth anus

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19
Q

What are the derivatives of the sections of the trilaminar disk?

A

organs structures
contact with outside world
nervous system
epidermis

supporting tissues
muscle cartilage bone
vascular system

internal structures
epithelial lining of GI
respiratory tract too

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20
Q

What is situs invertus?

A

mirror image
immotile cilia
problem forms from both normal and mirror image

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21
Q

Describe the left right asymmetry

A

bilaterally symmetrical
l lung two lobes r lung three lobes
thoracic and abdominal viscera

primitive node
ciliated cells
left ward flow of signalling molecules
without get right sidedness

22
Q

Describe the function of the notochord

A
rod of cells
midline
conversion ectoderm
signalling molecules
endoderm not have receptors
23
Q

How does the neural plate form?

A

ectoderm thickens

neural tube formation:
edges elevate out of plane of disk
curl
SEE CARD 27

24
Q

Label the new different parts of the mesoderm

A
paraxial
intermediate
somatic
splanchnic
intraembryonic coelom
25
What are somites? What is the organised degeneration that follows?
``` paraxial mesoderm 31 in total start off with 1st pair at day 20 in occipital region before gastrulation more appear in a craniocaudal sequence 42 to 44 pairs at the end of week 5 some disappear regular block mesoderm cells small cavity ``` ``` organised degeneration: ventral wall sclerotome further organisation of the dorsal portion forms... myotome dermatome ```
26
What are the somite derivatives?
``` dermatome - dermis myotome - muscles sclerotome - bones ```
27
How does folding occur?
neural tube curl under yolk sac cephalocaudal folding lateral folding see images
28
What does folding achieve?
``` margins ventral body wall amniotic membrane amniotic sac connecting stalk ```
29
What happens at the end of the fourth week?
nervous system segments folded embryo
30
What holds cells together?
cell cell adhesion molecules extracellular matrix proteins internal external scaffolding close proximity
31
What are the epithelial cell adherence systems?
lateral surface - 5 basal surface - 5
32
What are tight junctions?
location? fusion point function? paracellular transport
33
What are adhesion junctions?
``` location? pairs formed from? e- cadherin adhesion belt function? ```
34
What are desmosomes?
``` strongest location? random mechanical stress cytokeratin e- cadherin function? epidermal cells ```
35
What are gap junctions?
``` location? cardiac and smooth muscle function? Smooth muscle contraction sperm, RBC and motile cells cylinders of proteins connexin switch ```
36
What are hemi- desmosomes?
``` location? extracellular matrix cytokeratin, laminin basal lamina function? ```
37
What are focal adhesions?
similar function actin filaments integrins fibronectin
38
What are integrins?
``` cohesive forces alpha beta dimer extracellular matrix focal adhesion kinase binding capacity eg skin ```
39
What do all of these adhesion properties/ proteins require?
presence of calcium ions in order to function if insufficient Ca inside cell/ outside cell, adhesion molecules can't hold in place
40
Describe the mucosal membrane
``` definition continuous mucus function? examples ```
41
What are the layers in the GI tract?
``` mucosa muscularis mucosae submucosa muscularis externa serosa ```
42
Describe the structure- function relationships in the oesophagus
epithelium submucosa muscularis externa
43
Label the layers in the stomach
rugae 3 layers of smooth muscle in stomach- ME how are rugae held in this position?
44
Label the layers in the jejunum
jejunum- middle segment of the small intestine plicae circulares at this stage what is the function of these layers/ structures two layers to the ME
45
Label the layers in the colon
``` colon= large intestine MM at this magnification simple columnar epithelium water and electrolytes Lieberkuhn- function? aggregations of lymphoid tissue ```
46
What is the function of the mucosa in the GI tract?
absorb prevent move epithelial specialisations lamina propria muscularis mucosae muscularis externa
47
Describe the structure of the urinary tract
``` structural unit = nephron corpuscle lining square shaped proximal tubes basal lamina ```
48
Where is the muscle first appearing in the GI tract?
ureter and bladder | urothelium
49
Describe the structure of the bladder and the urethra
``` fat shock absorber mucus acidic urine protection tight junctions function of transitional epithelium ``` ``` similar squamous ➡️ keratinised squamous mucus glands absorption prevention removal ```
50
Describe the structure of the respiratory tract, trachea and primary bronchi, alveolus
gaseous conducting and respiratory ``` trachaelis muscle hyaline cartilage ring primary similar but cartilage and spiral muscle differences food? mucosa submucosa c shaped hyaline cartilage secretions from epithelium and submucosal glands contain? cilia wave mucociliary escalator ``` flattened specialised epithelium folds in basal lamina at the juntion connective tissue
51
Describe the mucociliary escalator in the trachea
``` unusually thick lamina propria elastic fibres sugar white patches GOBLET CELL ```
52
What are the secondary and tertiary bronchi?
``` similar cartilage no longer present epithelium pseudostratified smooth muscle seromucous glands crescent shaped no outer layer of smooth muscle ```