Flashcards in Session 3: Asthma Deck (15):
What are the 3 things that are wrong in Asthma?
1. Lung Hyper reactivity
2. Lung hyper sensitivity
3. WBC infiltrates into the wall
Name 4 triggers of asthma
5. Drugs (NSAID)
What can be causes of occupational asthma?
What are the two types of asthma?
2. Non eosinophilic
What happens in eosinophilic asthma?
The allergen has PAMP on its surface. These antigens are processed by APC and is put on their cell as MHC II antigens.
Naive T cells then come along are activated and become CD4 lymphocytes. Release IL4 and IL13 causes SM contraction
Stimulates B cells and makes Ig E.
The excessive Ig E binds to mast cells and eosinophils and causes there to be degranulation and histamine release. Also prostaglandin D2
These cause vasodilation and broncho constriction.
What can prostaglandin do?
It can stimulate SM contraction and illicit pain receptors
What stimulates T cell activation and subsequent B cell activation in Non eosinophilic asthma?
You can get stimulation from
DAMPS. TLR and Complement factors
Give 5 differentials for a persistent cough
Give 5 differentials of a dry cough?
Name 4 causes of SOB
- Panic attack
How can we diagnose Asthma?
- Look for diurnal variation of >15% in peak flows in a peak flow diary
- Spirometry look for a obstructive pattern
- NO test concentration
- Allergy testing
What do you give in an asthma attack?
- Nebulised Salbutamol
- Ipratropium Bromide
What level of PEFR is classed as severe/life threatening?
< 33% or having a silent chest
What PEFR is classed as acute severe asthma?