Session 3: Asthma Flashcards Preview

PHASE 2A: EYGP > Session 3: Asthma > Flashcards

Flashcards in Session 3: Asthma Deck (15):
1

What are the 3 things that are wrong in Asthma?

1. Lung Hyper reactivity
2. Lung hyper sensitivity
3. WBC infiltrates into the wall

2

Name 4 triggers of asthma

1. Cold
2. Damp
3. Exercise
4. Allergens
5. Drugs (NSAID)
6. Pollution

3

What can be causes of occupational asthma?

- Latex
- Flour
- Animals
- Pollen
- Dust

4

What are the two types of asthma?

1. Eosinophilic
2. Non eosinophilic

5

What happens in eosinophilic asthma?

The allergen has PAMP on its surface. These antigens are processed by APC and is put on their cell as MHC II antigens.
Naive T cells then come along are activated and become CD4 lymphocytes. Release IL4 and IL13 causes SM contraction
Stimulates B cells and makes Ig E.
The excessive Ig E binds to mast cells and eosinophils and causes there to be degranulation and histamine release. Also prostaglandin D2
These cause vasodilation and broncho constriction.

6

What can prostaglandin do?

It can stimulate SM contraction and illicit pain receptors

7

What stimulates T cell activation and subsequent B cell activation in Non eosinophilic asthma?

You can get stimulation from
DAMPS. TLR and Complement factors

8

Give 5 differentials for a persistent cough

GORD
Lung Cancer
COPD
Bronchiectasis
TB

9

Give 5 differentials of a dry cough?

Pulmonary Embolus
Asthma
Pulmonary fibrosis
Adenovirus infection
Pulmonary fibrosis

10

Name 4 causes of SOB

- Pneumothorax
-Pulmonary Embolism
- Panic attack
- LRTI

11

How can we diagnose Asthma?

- Look for diurnal variation of >15% in peak flows in a peak flow diary
- Spirometry look for a obstructive pattern
- NO test concentration
- Allergy testing

12

What do you give in an asthma attack?

You give
- Oxygen
- Nebulised Salbutamol
- Ipratropium Bromide
- Prednisolone

13

What level of PEFR is classed as severe/life threatening?

< 33% or having a silent chest

14

What PEFR is classed as acute severe asthma?

33-50%

15

What PEFR is classed as moderate asthma?

50-75%