Session 4: Reproductive and Post-reproductive Health Flashcards
What are sex steroids synthesised from?
Cholesterol
Briefly explain the sex steroid synthesis.
Cholesterol -> pregnenolone -> progesterone -> testosterone -> estradiol.
CYP17 turns progesterone into testosterone.
Explain the properties of the steroid hormone receptor.
Classic nuclear receptor that exert effects through gene transcription.
It is also a membrane receptor for oestrogen.
Major effects of oestradiol
Stimulates growth of the endometrium and breast.
It also stimulates production of progesterone receptors.
Major effects of progesterone.
Stimulates growth of the endometrium and brest.
Maintains pregnancy
Also inhibits production of oestrogen receptors.
Major effects of testosterone
Stimulates male characteristics
Hairy body
Deep voice
Anabolism
Aggression
Other oestrogen actions.
Mildly anabolic
Sodium and water retention
Raises HDL and lowers LDL
Decrase bone resportion
Impair glucose tolerance
Increase blood coagulability
Side effects of oestrogen.
Breast tenderness
Nausea and vomiting
Water retention
Increased blood coagulability
Thromboembolism
Impaired glucose toelrance
Endometrial hyperplasia and cancer
Ovarian metaplasia and cancer
Breast hyperplasia and cancer
Other progesterone actions.
Secretory endometrium
Anabolic effects
Increases bone mineral density
Fluid retention
Mood changes
Maintains pregnancy
Side effects of progesterone
Weight gain
Fluid retention
Anabolic
Acne
Nausea
Vomiting
Irritability
Depression
PMS
Lack of concentration
Actions and side effects of testosterone.
Male secondary sex characteristics
Anabolic
Acne
Voice changes
Increased aggression
Increased risk of atherosclerotic disease in males due to the HDL-C/LDL-C ratio being lower.
Where is oestrogen absorbed?
Natural and synthetic oestrogens well absorbed in the GI tract and also readily absorbed from skin and mucous membranes.
Where is oestrogen metabolised?
Liver
Where is oestrogen excreted?
In the urine as glucuronides and sulfates.
Explain the pharmacokinetics of progesterone.
Injected progesterone is bound to albumin with some stored in adipose tissue.
Metabolised in the liver and then excreted in the urine conjugated to glucuronic acid.
Adverse effects of the COCP.
Risk of thromboembolism which is however usually small but severely increased with smoking.
More commonly associated with other risk factors such as obesity and hypertension.
Where are COCP and POP contraceptives metabolised?
In the liver by CYP 450 enzymes.
Give examples of drugs that reduce oral contraceptive efficacy and why.
Anti-epileptics like carbamazepine or phenytoin.
Antibiotics such as rifampicin and rifabutin.
Some natural products such as St John’s Wort.
These all cause an increase in the production of hepatic CYP450.
Explain the interaction between soya protein and oestrogen.
Enhance oestrogen absorption and reduce its storage in adipose and muscle.
This menas that the half-life is reduced from 15 hours to 7 hours.
Why is HRT prescribed?
To deal with the peri-menopausal, menopausal and post-menopausal effects.
For symptoms such as hot flushes/sweats and dyspareunia.
Osteoporosis
However no effect on heart disease.
Give examples of steroids used in HRT.
Oestradiol such as valerate, enanthate, micronised oestradiol, ethinyl estradiol.
Premarin
Provera
Norethisterone
Levonorgestrel
Routes of administration of HRT.
Oral
Transdermal
Implant
Transvaginal
Nasal
Should HRT be given in prevention of heart disease?
No it is not effective for it and should not be prescribed for it.
Risks of HRT.
Unopposed oestrogen leading to increased risk of developing endometrial and ovarian cancers.
Opposed oestrogen increases risk of developing breast cancer.
Increased risk of venous thromboembolism.
Increased risk of stroke
