Flashcards in Set 6 Deck (60)
MC breast tumor in pre-, peri- and post-menopausal women?
pre = fibroadenoma (benign)
peri = intraductal papilloma (benign, unilateral bloody discharge)
pst = DCIS (+/- discharge)
HIV drug causing pancreatitis
2 diseases associated with angiodysplasia in elderly?
Aortic stenosis (called Heyde's Syndrome)
obese diabetic with hepatomegaly and transaminitis? a/w? mechanism?
NASH, 2/2 insulin resistance causing increased rate of lipolysis and circulating insulin
a/w obesity, DM2, HLD and TPN
Immunocompromised pt with FOCAL neurologic deficits? Findings?
PML --> MRI w/ multiple demyelinating NON-enhancing lesions, no masses effect
anteromedial tibeal swelling/pain, normal xray, negative valgus stress test (vs. MCL injury)
HIV drug CLASS causing SJS
Dx and 2nd line Tx for lyme disease
Dx = ELISA/WB
Tx = doxcycline 1st, amoxicillin 2nd
HIV drug causing liver failure
Hemorrhage vs. infarct on CT
hemorrhage = HYPERdense
infarct = hypodense
Worst type of mutation in NF2, inheritance?
Nonsense mutation (severe variant)
all are AD
photophobia, painful red eye, non-reactive mid-dilated pupil? dx, tx?
acute closed-angle glaucoma
dx = tonometry
tx = acetazolamide (decrease pressure) then pilocarpine (relieve obstruction)
deformed feet, joint effusions, osteophytes and bone fragments?
Charcot's joint = neurogenic arthropathy 2/2 neuropathy and repeated wt-bearing trauma
What happens to levels of ACTH, aldosterone, cortisol and ADH if chronic steroid patient abruptly stops?
central, tertiary adrenal insufficiency
decreased ACTH, cortisol
increased ADH (normally suppressed by cortisol)
2 risks of tamoxifen use?
cancer (endometrial CA, uterine sarcoma)
Acid-base disturbance in ASA overdose?
mixed respiratory alkalosis and AG metabolic acidosis (NOT a compensatory respiratory alkalosis though!)
conjunctivitis in neonate, 3 ddx and how to differentiate
chemical = 1st 24hrs, no pus
gonococcal = 2-5 days with purulence
chlamydia = 5-15 days, less pus
When to do EGD in GERD
fail empiric tx OR
**complicated GERD = dysphagia, odynophagia, wt loss, bleeding or iron deficiency
3 MCC bacterial rhinosinusitis? tx?
S pneumo, H flu, M catarrhalis
6 causes of drug-induced esophagitis
Tetracyclines, ASA/NSAIDs, Alendronate, KCl, Quinidine, Iron
urine/serum osmolality in osmotid diuresis
both elevated but urine > serum
3 dx features of Wilson's Disease
Increased urinary copper
Kayser-Fleischer rings on slit lamp eye exam
most and least malignant potential regarding colon polyps
Most = sessile, villous adenoma >2.5cm
Least = hamartomatous and hyperplastic (~benign)
Iron, TIBC, ferritin, transferrin sat% in anemia of chronic disease
Decreased = iron, TIBC, transferrin, ~transferrin sat%
OI pathogenesis, PE findings (4)
type 1 collagen disorder
PE = blue sclera, hearing loss, hypermobile joints, dentinogenesis imperfecta
Fall on oustretched hand resulting in Positive drop-arm test (can't hold it up)
rotator cuff tear = supraspinatus injury which controls first 15 degrees of abduction
Migratory thrombophlebitis indicates? W/u?
aka Trousseau's Syndrome --> indicates likely underlying malignancy MCC adenocarcinoma (pancreas > lung > prostate > gastric)
Dx = CT abdomen
Hemolytic anemia + hepatic vein thrombosis, think...pathogenesis?
Paroxysmal nocturnal hemoglobinuria --> ACQUIRED defect in GP1 anchor responsible for CD55/59 anchoring to RBCs to keep from being targeted by complement
acute* symmetric, polyarticular arthritis
viral! MCC parvo B19