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Flashcards in shock turner Deck (40)
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1

what is the difference b/n anaphylactic shock and septic shock?

septic shock is due to an actual threat. Anaphylactic shock is due to a perceived threat

2

what kind of hypersensitivity is anaphylactic shock

type 1

3

typical symptoms associated with anaphylactic shock

difficulty breathing, edema, AMS, arrhythmia, atopic

4

where do b cells learn tolerance?

bone marrow

5

what is the difference b/n positive and negative selection

+ = do you recognize self
- = do you recognize self too strongly

6

no thymus is what dieseae

di georges

7

where do b and t cells hang out

lymph nodes

8

how do t and b cells enter the lymph node

HEV

9

how do dendrtic cells enter lymph nodes

affarent lymphatic vessels

10

where do b cells go winthing the lymph node

germinal center

11

a person is deficinet in germinal centers what could this mean

deficient in B cels

12

t cells can only recognize what

polypeptides

13

what is the most important antibody in type 1 hypersensitivty

IgE

14

what cytokine is needed for class switching from IgM to IgE

IL-4

15

What is the very first antibody ever made by a b cell

IgM

16

What is the most important cell involved in anaphylactic rxn

mast cells

17

What specific subset of t cells is involved in parasites and allergies

TH2

18

What are the 3 major cytokines that TH2 secretes

IL-4, IL-5, IL-13

19

Where does IgE bind

to the FC region on the surface of mast cells and cross links

20

what 2 cytokines increase the production of mucus

IL-4, IL-13

21

What enhances mast cell differentiation

IL-9

22

can free-floating IgE cause anaphylactic rxn

No, only bound

23

what is sensitization

the pt has been previously exposed to an allergen so IgE is already bound to the surface of mast cells. So the second exposure will be fast bc cross-linking is fast

24

what signal is needed inside the cell for histamine to be released

ITAMs - in models where no itams there is no anaphylactic shock!

25

what do eosinophils release in response to anaphylactic shock

major basic protein which damages parasites

26

What is given to pts to help with late-phase hypersensitivity reaction

corticosteroids

27

what is given to pts undergoing anaphlactic shock

epinephrin

28

is DEsensitization what antibodies will someone begin making

they go from IgE (TH2) to IgG (TH1)

29

What are key features of septic shock

fever, elevated WBC, elevated neutrophils and band cells, an actual pathogen

30

what is a key superantigen in causing septic shock

staph areus , cause nonspecific activating of t cells