SI Lec - Innate Immunity Flashcards Preview

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Flashcards in SI Lec - Innate Immunity Deck (57):
1

- includes all parts of the body that help in the recognition and destruction of foreign materials.

Immune System

2

is the body's ability to fight off harmful micro-organisms –PATHOGENS- that invade it.

Immunity

3

2 types of immunity

innate
adaptive

4

____ immunity occurs when when one makes his/her own antibodies. This type of immunity is long term.

Active

5

If you get an infectious disease (like Chicken Pox), often times, that stimulates the production of ____ cells which are then stored to prevent the infection in the future.

MEMORY

6

purely an injection of antibodies to provide temporary immunity.

Gamma Globulin shot

7


-also called innate immunity






Natural Immunity

8

-non specific/non-adaptive immunity

Natural Immunity

9

type of immunity: -same response for all pathogens

Natural Immunity

10

type of immunity
-ability to resist infection by means of normally present body functions

Natural Immunity

11

type of immunity
no prior exposure is required





Natural Immunity

12

type of immunity
response does not change upon repeated exposure

Natural Immunity

13

type of immunity
influenced by factors like nutrients, age, fatigue, stress and genetic determinants

Natural Immunity

14

Natural Immunity influenced by what factors

nutrients, age, fatigue, stress and genetic determinants

15

defense mechanism of natural immunity

keep microorganisms from entering the body

External defense mechanism

16

defense mechanism of natural immunity

involve
both cellular and humoral factors

Internal defense mechanism

17

includes physical, chemical, and cellular barriers


Innate Immune System

18

barrier of
Innate Immune System
eg. skin and mucous membranes

physical

19

barrier of
Innate Immune System
eg. stomach acidity, secreted anti-microbial peptides

chemical barriers

20


barrier of Innate Immune System
eg. macrophages, neutrophils

cellular

21

innate immune response activation occurs within __ (how long) of pathogen recognition

minutes

22

Structural barriers that prevent microorganisms from entering the body

External Defense System

23

External Defense System
components (3)

Intact skin
Mucous membranes
Secretions

24

anti-fungal peptides called (intestinal tract)

alpha-defensins

25

anti-microbial peptides called (respiratory, urogenital tract)

beta-defensins

26

opsonize pathogens for enhanced phagocytosis (lung)

surfactant-A and -D proteins

27

location
lactic acid (2)

sweat
vagina

28

location
fatty acids

sebaceous glands

29

location
- lysozyme

saliva
tears

30

location
acid pH

stomach

31

location
alpha-defensins

intestinal tract

32

location
beta-defensins

RT and urogenital tract

33

location
surfactant-A and -D proteins

lungs

34

Epithelial defense mechanisms (3)

Flushing action of urine (also acid pH)

Motion of the cilia

Presence of normal flora (competitive exclusion)

35

components of internal defense system

Cells and soluble factors

36

what defense system Recognize molecules

internal defense system

37

Normal serum constituents
Increase rapidly due to infection, trauma, injury

Acute Phase Reactants

38

Normal serum constituents
enhances phagocytosis

Acute Phase Reactants

39

Acute Phase Reactants produced by

hepatocytes

40

Acute Phase Reactants produced by hepatocytes within __ in response to __

12-24 hours in response to cytokines

41

intracellular signaling polypeptide; produced mainly by macrophages at the sites of inflammation

Cytokine

42

Cytokine- intracellular signaling polypeptide; produced mainly by ____

macrophages at the sites of inflammation

43

Trace constituent of serum

Declines rapidly w/ cessation of stimulus

C-Reactive Protein

44

Thought to be an antibody to the c-polysaccharide of pneumococci

C-Reactive Protein

45

increases w/in 4-6 hours following infection, surgery, trauma

C-Reactive Protein

46

Peaks w/in 48 hours

C-Reactive Protein

47

C-Reactive Protein
Peaks w/in ? hours

48

48

C-Reactive Proteinincreases w/in ?? hours following infection, surgery, trauma

4-6

49



= common constituent of microbial membrane

phosphocholine

50

Belongs to the family of pentraxins

CRP

51

Acts like an antibody (primitive ab)

CRP

52

Capable of opsonization, agglutination, precipitation, C’ activation

CRP

53

Ca dependent, non-specific

CRP

54

substrate of CRP

Phosphocholine

55

Half life of CRP

19 hours

56

MW of CRP

= 118000 daltons

57

Uses of CRP

Indicator of acute inflammation
Non-specific indicator of disease or trauma
Following course of malignancy and organ transplantat

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