SI LEC - Innate Immunity Part 2 Flashcards Preview

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Flashcards in SI LEC - Innate Immunity Part 2 Deck (63):
1

Serum Amyloid A assoc with

HDL-Cholesterol

2

Apolipoprotein
MW = ??

11, 685 daltons

3

Normal circulating levels of SAA

30 µg/mL

4

Functions of SAA

Cleaning up chole from macrophages at the site of tissue injuries
Recycles cell membrane cholesterol

5

Series of serum proteins that are normally present
Major functions include:
opsonization
chemotaxis
cytolysis

Complement

6

complement Major functions include:

opsonization
chemotaxis
cytolysis

7

Mannose-Binding Protein also called

Aka mannose-binding lectin

8

Trimer
Acts as an opsonin
Ca-dependent

Mannose-Binding Protein

9


Recognize foreign CHO found on bacteria, yeasts, viruses, parasites



Mannose-Binding Protein

10

Activates C’, helps promote phagocytosis

Mannose-Binding Protein

11

Normal concentration = of MBP

10 µg/mL

12

Uninhibited proteases can remain in lower resp tract and destroy parenchymal cells = development of ___

emphysema

13


endogenous ENZ that degrade elastin and collagen

Elastase :

14

Major component of the alpha band in SPE
Plasma inhibitor of proteases released from WBC (eg. elastase)

Alpha1-antitrypsin

15

Acts a “mop-up” or counteracts the effect of neutrophil invasion during inflammation

Alpha1-antitrypsin

16

Can also react w/ serine proteases triggering C’ cascade or fibrinolysis

Alpha1-antitrypsin

17

Regulates expression of pro-inflammatory cytokines

Alpha1-antitrypsin

18

An Alpha2- globulin

haptoglobin

19

MW of haptoglobin

100 000

20

Binds free hgb (released by intravascular hemolysis) irreversibly

haptoglobin

21

Hgb Haptoglobin complex cleared by

liver

22

haptoglobin levels may ___ because of intravascular hemolysis: must be interpreted in the light of other APR

drop

23

Normal plasma conc= 40 to 290 mg/dL what acute reactant protein

haptoglobin

24

haptoglobin Normal plasma conc

40 to 290 mg/dl

25

Unfolded CHONS __ in blood vessels

aggregate

26

plays a role in protecting kidneys from damage

haptoglobin

27

prevents loss of iron

haptoglobin

28

prevents oxidative damage of free hgb

haptoglobin

29

Most abundant coagulation factor


fibrinogen

30

Normal levels= 100 to 400 mg/dL

fibrinogen

31

forms fibrin clots

Fibrinogen

32

trimer

mannose-binding protein

33

dimer

fibrinogen

34

fibrinogen normal levels

100 to 400 mg/dl

35

MW = 340, 000 daltons

fibrinogen

36

MW of fibrinogen

340 000

37

Increases the strength of the wound



Fibrinogen

38

Promotes aggregation of RBCs
can increased risk of developing CAD

Fibrinogen

39

Forms a clot; a barrier to prevent spread of microbes

Fibrinogen

40

Stimulates endothelial cell adhesion and proliferation

Fibrinogen

41

autosomal recessive genetic disorder
Co accumulates in the liver, brain, cornea, kidneys,

Wilson’s dx

42

Acts as ferroxidase

Ceruloplasmin

43

the principal Co-transporting protein in the human plasma

Ceruloplasmin

44

MW= 132, 000 daltons

Ceruloplasmin

45

Binds 90-95% copper found in the plasma

Ceruloplasmin

46

help make neutrophils sticky and enhance adherence to endothelial cells

Selectins:

47

movement thru blood vessel walls.

diapedesis

48

NEUT form __ which squeeze thru junctions

pseudopods

49

chem’l messenger that cause cells to migrate in a particular direction

chemotaxins

50

Life span of neutrophil in the tx:

5 days

51

w/ primary and specific granules
Capable of phagocytosis but not as efficient as neutrophil
Neutralizing basophils and mast cells
Killing parasites

Eosinophils

52

vasoactive amine that contracts smooth muscle

Basophils

53

immunoglobulin that binds to surface of basophil

IgE

54

lifespan of basophils

few hours

55

Basophils that have migrated to the tissues.

Mast Cells

56

Largest in the peripheral blood

Monocytes

57

granules of monocytes (6)

peroxidase
ACP
arylsulfatase
beta-glucuronidase
lysozyme
lipase

58

monocytes Stay in peripheral blood up to ?? hours

70

59

as macrophage become monocytes, there is an increase in __

Increase in ER, lysosomes, and mitochondria

60

w/ progressive cellular enlargement to b/w 25-80 um

tissue macrophage

61

Long lived but slow in motility

monocytes

62

Fxn: microbial killing, tumoricidal, intracellular parasites eradication, phagocytosis, secretion of cytokines, Ag presentation

monocytes

63

main fxn of dendritic cells

Phagocytose Ag and present in T helper cells

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