SI LEC - Innate Immunity Part 3 Flashcards Preview

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Flashcards in SI LEC - Innate Immunity Part 3 Deck (24):
1

Covered by long membranous extensions

Dendritic cells

2

dendritic cell in
skin/mucous membrane


Langerhans cells:

3

dendritic cell
organs like heart

Interstitial cell:

4

dendritic cell
T lympho areas in secondary lymphoid organs

Interdigitating cell:

5

cytokines are critical for host defense.

inflammatory cytokines

6

ex of inflammatory cytokines
activates macrophage and PMN phagocytosis and killing

TNFa

7

ex of inflammatory cytokines
activates anti-viral mechanisms

IFNab

8

ex of inflammatory cytokines
stimulates inflammation and fever

IL-1

9

Cytokines

- can function in __ or __ manner

autocrine or paracrine

10

bind specific and sometimes shared receptors to recruit various types of immune cells to the site of infection

chemokines

11

-diverse family of chemotactic cytokines, induce directed chemotaxis of cells
all related in amino acid structure

-promiscuous in receptor usage, each can bind more than one receptor

-likewise, receptors are promiscuous

Chemokines

12

certain chemokines induce cell ____ in addition to cell recruitment

activation

13

smallest granulocyte

basophilia

14

protein discovered in drosophilia (fruit fly) (antifungal)

Toll

15

Toll: protein discovered in

drosophilia (fruit fly) (antifungal)

16

TLR for bacterial parasites

TLR 1 and TLR 2

17

TLR for gram negative bacteria and fungi

TLR 2 and TLR 6

18

TLR for gram +

TLR 4

19

TLR for flagellated

TLR 5&7

20

TLR for viral dsRNA

TLR 3

21

TLR for viral ssRNA

TLR 3& 7

22

Bacterial DNA elements

TLR9

23

what TLRs: Lysosomal localization / what TLRs are subcellular

TLR-3 and TLR7-9

24

TLR-??
recognize viral/bacterial nucleic acids

TLR-3 and 7-9

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