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Flashcards in SI LEC - Scientists II Deck (22):
1

: used skin grafts to show that tolerance is acquired characteristics of the lymphoid cells – a key feature of clonal selection theory

PETER MEDAWAR

2

: proposed the first generally accepted clonal selection hypothesis of adaptive immunity

FRANK MaCFARLANE BURNET

3

reported that dizygotic twin cattle, which were true chimeras, were immunologically tolerant of each other tissues and serum –- description of tolerance (chimerism) in dizygotic cattle twins.

RAY OWEN:

4

worked out the genetics on murine MHC & generated the congenic strains needed for its biological analysis laying the groundwork for our current understanding of MHC in T cell biology.

GEORGE SNELL:

5

developed precipitin test in gels and the idiotypes.

JACQUES OUIDIN:

6

discovered immunoglobulins as “transporteurs”

PIERRE GRABAR:

7

developed double immunodiffusion test in gels.

ORJAN OUCHTERLONY & STEPHEN ELEK:

8

discovered plasma cells as antibody producing cells.

ASTRUD FARGAEUS:

9

provided experimental evidence of acquired immunologic tolerance

ILAN HASEK:

10

was an early pioneer in the study of the human major histocompatibility complex or HLA

JEAN DAUSSET:

11

: introduced radioimmunoassay

ROSALYN YALOW

12

made crucial discoveries about the structure of immunoglobulins, the first complete sequence of antibody molecule.

GERALD EDELMAN:

13

discovered IgE as reaginic antibody.

KIMISHIGE ISHIZAKA:

14

discovered that bursa of Fabricius is responsible for generating the cells capable of manufacturing antibodies – B cells

NOEL WARMER:

15

were interested in transplantation

E. DOUMAL THOMAS & JOSEPH MURRAY:

16

discovered immune response genes and collaborated in the first demonstration of MHC restriction

BARUJ BENACERRAF:

17

discovered that adaptive immunity is mediated by lymphocytes, focusing the attention of immunologists on these small cells.

JAMES GOWANS:

18

developed the hemolytic plaque assay and several important immunological theories, including an early version of clonal selection, a prediction that lymphocyte receptors would be inherently biased to MHC recognition, and the idiotype

NIELS JERNE:

19

pioneered monoclonal antibody production from hybrid antibody-forming cells with Cesar Milstein

GEORGE KOHLER:

20

pioneered monoclonal antibody production George Kohler

CESAR MILSTEIN:

21

worked out the polypeptide structure of an antibody molecule, layering the groundwork for its analysis by protein sequencing

RODNEY PORTER:

22

discovered the somatic recombination of immunological receptor genes that underlies the generation of diversity in human and murine antibodies and T cells receptors.

SUSUMO TONEGAWA:

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