Flashcards in SI LEC - Scientists II Deck (22):
: used skin grafts to show that tolerance is acquired characteristics of the lymphoid cells – a key feature of clonal selection theory
: proposed the first generally accepted clonal selection hypothesis of adaptive immunity
FRANK MaCFARLANE BURNET
reported that dizygotic twin cattle, which were true chimeras, were immunologically tolerant of each other tissues and serum –- description of tolerance (chimerism) in dizygotic cattle twins.
worked out the genetics on murine MHC & generated the congenic strains needed for its biological analysis laying the groundwork for our current understanding of MHC in T cell biology.
developed precipitin test in gels and the idiotypes.
discovered immunoglobulins as “transporteurs”
developed double immunodiffusion test in gels.
ORJAN OUCHTERLONY & STEPHEN ELEK:
discovered plasma cells as antibody producing cells.
provided experimental evidence of acquired immunologic tolerance
was an early pioneer in the study of the human major histocompatibility complex or HLA
: introduced radioimmunoassay
made crucial discoveries about the structure of immunoglobulins, the first complete sequence of antibody molecule.
discovered IgE as reaginic antibody.
discovered that bursa of Fabricius is responsible for generating the cells capable of manufacturing antibodies – B cells
were interested in transplantation
E. DOUMAL THOMAS & JOSEPH MURRAY:
discovered immune response genes and collaborated in the first demonstration of MHC restriction
discovered that adaptive immunity is mediated by lymphocytes, focusing the attention of immunologists on these small cells.
developed the hemolytic plaque assay and several important immunological theories, including an early version of clonal selection, a prediction that lymphocyte receptors would be inherently biased to MHC recognition, and the idiotype
pioneered monoclonal antibody production from hybrid antibody-forming cells with Cesar Milstein
pioneered monoclonal antibody production George Kohler
worked out the polypeptide structure of an antibody molecule, layering the groundwork for its analysis by protein sequencing