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Schizophrenia > Side Effects > Flashcards

Flashcards in Side Effects Deck (40):
1

Aripiprazole

Little weight gain
Least sedating
PO and LAI

2

Maintena

Gluteal injection
14 day oral overlap
Monthly injection

3

Aristada

Gluteal injection
21 day oral overlap
Monthly or 6 week injection

4

1st gen class side effects

EPS
QTc prolongation
Prolactin elevation
Dermatologic
Photosensitivity
Blue gray skin
Orthostatic hypotension
Altered thermoregulation

BBW: dementia

5

2nd gen class side effects

Metabolic syndrome
QTc prolongation
Blood dyscrasia/ agranulocytosis
Seizure threshold
Anticholinergic
Sedation
Prolactin elevation (2)

BBW: dementia

6

Can skip right to clozapine when?

Severely suicidal
EPS Extreme
History of violence
Substance abuse

7

B52 is?

LAI haloperidol and lorazepam

8

Cannot mix IM with what drug

Olanzapine

9

Asenapine

2nd gen
Sublingual only
Black cherry taste
Can't eat or drink for ten minutes after
HIGH RISK QTC PROLONGATION

10

Long half life

Brexpiprazole
Cariprazine

11

Agranulocytosis

Clozapine

12

Orthostatic hypotension

Iloperidone
Slowly titrate

13

Rems monitoring ANC only

Clozapine

Olanzapine

14

When dose greater than 600mg/day seizure risk

Clozapine--must add anti epileptic

15

If metabolic gets bad?

DO NOT STOP CLOZAPINE--we change the metabolic syndrome not clozapine

16

Severe hepatic impairment don't use this drug

Iloperidone

17

LAI injection must observe for at least three hours bc respiratory suppression

Olanzapine

Pamoate zyprexa relprev

18

DRESS drugs reaction with eosinophilia and systemic symptoms

Dermatologic condition
Rash topically
But affects organs inside
Fatal if not caught

19

DRESS DRUGS

Olanzapine
Ziprasidone

20

OROS ghost tablet in stool

Paliperidone

21

Invega sustenna

Paliperidone
No PO overlap needed
Monthly injections
Deltoid or glute

22

Invega Trinza

Paliperidone
Every 3 month injection
MUST BE ON SUSTENNA FOR 3 MONTHS BEFORE

23

Quetiapine

Very sedating
Weight gain

24

Short acting injections

Chlorpromazine
Haloperidol
Fluphenazine
Olanzapine
Ziprasidone

25

Long acting injections

Fluphenazine
Haloperidol
Aripiprazole
Olanzapine
Risperidone
Paliperidone

26

Gluteal injection only

Olanzapine
Aripiprazole

27

EPS

Extra pyramidal symptoms
Use AIMS to confirm before stopping meds QUICKLY

28

Neuroleptic malignant syndrome NMS

High potency drugs
Onset: any time early treatment
Rapidly over 24-72 hrs
Labile BP
Confusion
Increased muscle tone/rigidity
Increased WBC CPK LFTs
Treatment: DC antipsychotic (bromocriptine if need)
Rechallenge with different drug (sga)

29

Sedation

Chlorpromazine
Clozapine
Thioridazine

30

EPS

Fluphenazine
Haloperidol
Perphenazine
Thioxene

31

Anticholinergic

Chlorpromazine
Clozapine
Thioridazine

32

Orthostasis

Chlorpromazine
Clozapine
Thioridazine
Iloperidone

33

Weight gain

Olanzapine
Clozapine
Chlorpromazine

34

Prolactin

Risperidone
Paliperidone
Perphenazine
Thioxene
Fluphenazine
Haloperidol

35

Cardiovascular effects

Haloperidol
Chlorpromazine
Clozapine
Iloperidone
Ziprasidone

36

LAI doesn't need oral overlap

Paliperidone
Olanzapine

37

Acute dystonia

Painful prolonged muscle contraction of whole body trunk included
24-96 hrs after dose/drug change
High potency drugs or high dose fga
Treat: anticholinergics IM and benzo IM

38

Pseudo-Parkinson's

Bradykinesia, tremor, pill rolling
1-2 weeks after drug/dose change
Treatment: anticholinergics

39

Akathisa

Restlessness, pacing, shuffling
Hrs to days after drug/dose change
High potency fga, aripiprazole,risperidone
Treatment: propranolol

40

Tardive diskinesia

Tongue thrusting, chewing, lip smacking, twisting rocking IRREVERSIBLE
LATE
high potency or high dose fga
Treatment: none must prevent
Anticholinergics MASK symptoms