Signal Transduction 4: Relationship Of Signal Transduction To Disease And Review Flashcards Preview

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Flashcards in Signal Transduction 4: Relationship Of Signal Transduction To Disease And Review Deck (12):
1

What do B2-adrenoceptor agonists target?

GPCRS, to treat symptoms of asthma

2

What do b2-andrenoceptor agonists do?

Reverse bronchoconstriction associated with asthma (examples being; salbutamol (ventolin) and salmeterol (serevent))

3

What is similar to epinephrine and can act as a b-agonist?

Salbutamol

4

What does salbutamol do?

Binds, so the phosphorylated myosin light chain kinase causes muscle relaxation

5

What do diabetes drugs mimic?

The actions of natural glucoregulatory hormones (eg symlin mimics amylin)

6

Where is anylin produced?

Beta cells of pancreas

7

What does symlin do?

Reduces eating and causes weight loss but is rapidly metabolised so are developing long acting analogues

8

What does insulin do?

Helps balance blood glucose levels

9

How is insulin used as a diabetes drug?

It mimics the natural actions of this hormone at the insulin receptor (an RTK- receptor tyrosine kinase)

10

What can a melanocortin 4 receptor mutation cause?

Extreme obesity

11

What is cholera caused by?

Disrupted cell signalling

12

What does a cholera toxin do to the receptor?

It locks G into its active form, causing disease