SJS/TEN Flashcards Preview

MSI > SJS/TEN > Flashcards

Flashcards in SJS/TEN Deck (13):
0

PMS BiTches are NSFw and need to be fixed

- p: phenothalien, m: metronidazole, s: sulfas, b: barbiturates, t: tetracyclines, n: NSAIDs, s: salycilates, f: yellow food coloring
- fixed drug rxn
- typically single bulluos lesion

1

DRESS in AN HAT

- dress reaction: drug reaction with eosinophilia and systemic symptoms
- A: Abx (metro, sulfas), N: NSAIDs (meloxicam), H: HIV drugs (abacavir), A: allopurinol, T: tetracyclines

2

Drug reactions assoc with. EBV/HIV

EBV: aminopenicillins
HIV: sulfa drugs (Sulfa Sex)

3

Han Chinese susceptibility

HLA B1501: SJS/TEN in response to anticonvulsants (carbamazepine specifically)

4

SATAN will give you SJS

- S: sulfa
- A: allopurinol
- T: tetracycline
- A: anticonvulsants
- N: NSAIDs

5

HLA B1501/B1502

- 1501: SJS susceptibility with Han Chinese and anticonvulsants
- 1502: SJS susceptibility with white Europeans and allopurinol
~ 1301: in Europeans too

6

HLA B5701

Abacavir SJS susceptibility

7

Mediators of SJS/TEN (4)

- granulysin, granzyme B, perforin
- soluble fas ligand liberated by mellatoproteases
- granulysin associated with significant apos of keratinocytes

8

Prohapten vs. pharmacological

- pro hapten response: drugs digested to substrates which triggers covalent formation of immune molecule
- pharmacological response: non-covalent binding of drugs at MHC I triggering apoptotic response

9

Prognosis/diagnosis potential

High serum granulysin and high mobility protein B1

10

Admission to burn unit in relation to toxic epidermolytic necrolysis

~ 50% lower with delay

11

Nikolsky sign

Seperation of dermis from basal layer upon lateral pressure

12

Asboe-Hansen sign

- lateral expansion of bulla upon pressure