Skeletal Relaxants Flashcards
Dantrolene
Phenytoin analogues
Relaxes muscle by direct action
Mechanism: bind to ryanodine receptor on the sr
So ca channel will not open and no calcium’ without paralysis the
Contraction is weakened
Little effect on cardiac and smooth muscle
Adverse effects = dizziness,weakness,fatigue,diarrhoea
Therapeutic effects= to reduce the spascity for nursing care
Malinga hyperthermia = it is a reaction triggered by the inhalators anaesthetic ,depolarising muscle relaxant,curare like neuromuscular blocker or by stress
Calcium will be more in susceptible individuals
Leading to muscle rigidity it’s rare familial disorder
Hyperpyrexia, hyperkalemia, tachycardia, metabolic acidos
D tubocurarine
Dextrorotatory
Quaternary ammonium alkaloid
Mechanism of action = binds to nicotonic receptor and block the receptors from the acetylcholine on map by competitive.
If acetylcholine concerntration is increased or dtubocurarine is blocked it is reversed
Effects = sortable muscle motor weakness and flaccid paralysis, firstly the toes eyes ears are effected then diplopia and slurred speech swelling then comes to respiratory muscles and death may occurs
Autonomic ganglia= blockage even medulla is blocked
Hypotension
Histamine release= bronchospasm , secretions from passages of respiratory and gastric thing and last hypotension is produced
Absorption and fate and excretion = no cns bbb not much baby git
Adverse= hypotension hypoxia
Hypoxia= must be treated with positive pressure, neostigmine counter acts the muscle paralysis, enhances the bronco spasm and hypotension
It can be reverse by atropine
Hypotension = antihistamines is fluids
Regurgitation maybe there due to paralysis of oesopgus
