Flashcards in Sketchy - Cell Wall and Membrane Active Antibiotics - Penicillins Deck (22):
How do penicillins work their magic?
They interfere with the transpeptidation reaction of bacterial cell wall synthesis
Penicillin binding proteins do this by removing a terminal alanine in the D-ala-D-ala motif preventing cross-linking.
Penicillins work best against what kind of bacteria in general?
Gram positives ie staph and strep
The cell wall of gram positive organisms is made of:
peptidoglycan with repeating D-alanyl-D-alanine oligopeptides
T/F: Penicillin is bacteriocidal.
How is Penicillin V administered?
Orally - Penicillin V is acid stable
What is the dosing for Penicillin V?
Why is penicillin V not a great choice?
How is Penicillin G administered?
IV and IM
What is an appropriate treatment for Group A streptococcal pharyngitis?
What is an appropriate tx for rheumatic fever?
Pen V or G
What is an appropriate treatment for left-sided endocarditis caused by Strep viridans or Strep bovis?
What is the intrapartum treatment for Strep agalactiae (Group B strep)?
Pencillin G prophylaxis
What gram positive bacillus that grows in chains is treatable with penicillins?
T/F: Clostridium perfringens can be treated with penicillins.
What is an appropriate treatment for Pasturella multocida caused by dog bits?
What is the treatment of choice for Syphilis?
single dose of benzathine Penicillin G
Works for primary, secondary and early latent forms of syphilis
What gram negative organism can be treated with Penicillin G and causes meningitis?
What is the most common mode of resistance against penicillins?
The production of beta lactamases, such as those made by staph aureus
Penicillins can cause what a Type I hypersensitivity reaction resulting in:
Penicillin administration can result in what form of anemia as an adverse effect?
Autoimmune hemolytic anemia
Positive direct Coombs test
What adverse effect can penicillins have on the kidney?
Drug-induced interstitial nephritis