Sketchy - Cell Wall and Membrane Active Antibiotics - Penicillins Flashcards Preview

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Flashcards in Sketchy - Cell Wall and Membrane Active Antibiotics - Penicillins Deck (22):
1

How do penicillins work their magic?

They interfere with the transpeptidation reaction of bacterial cell wall synthesis

Penicillin binding proteins do this by removing a terminal alanine in the D-ala-D-ala motif preventing cross-linking.

2

Penicillins work best against what kind of bacteria in general?

Gram positives ie staph and strep

3

The cell wall of gram positive organisms is made of:

peptidoglycan with repeating D-alanyl-D-alanine oligopeptides

4

T/F: Penicillin is bacteriocidal.

True

5

How is Penicillin V administered?

Orally - Penicillin V is acid stable

6

What is the dosing for Penicillin V?

4x/day

7

Why is penicillin V not a great choice?

Frequent dosing;
Poor bioavailability

8

How is Penicillin G administered?

IV and IM

9

What is an appropriate treatment for Group A streptococcal pharyngitis?

Penicillin V

10

What is an appropriate tx for rheumatic fever?

Pen V or G

11

What is an appropriate treatment for left-sided endocarditis caused by Strep viridans or Strep bovis?

Penicillin G

12

What is the intrapartum treatment for Strep agalactiae (Group B strep)?

Pencillin G prophylaxis

13

What gram positive bacillus that grows in chains is treatable with penicillins?

Actinomyces israelii

14

T/F: Clostridium perfringens can be treated with penicillins.

True

15

What is an appropriate treatment for Pasturella multocida caused by dog bits?

Penicillins
Ampicillin
Piperacillin

16

What is the treatment of choice for Syphilis?

single dose of benzathine Penicillin G

Works for primary, secondary and early latent forms of syphilis

17

What gram negative organism can be treated with Penicillin G and causes meningitis?

Neisseria meningitidis

18

What is the most common mode of resistance against penicillins?

The production of beta lactamases, such as those made by staph aureus

19

Penicillins can cause what a Type I hypersensitivity reaction resulting in:

anaphylaxis

20

Penicillin administration can result in what form of anemia as an adverse effect?

Autoimmune hemolytic anemia

Positive direct Coombs test

21

What adverse effect can penicillins have on the kidney?

Drug-induced interstitial nephritis

22

Penicillins have cross-reactivity with what drug class?

Cephalosporins