Sketchy Pharm: Maraviroc, Fusion Inhibitors, Integrase Inhibitors Flashcards Preview

MS2 - USMLE Step 1: Part 2 > Sketchy Pharm: Maraviroc, Fusion Inhibitors, Integrase Inhibitors > Flashcards

Flashcards in Sketchy Pharm: Maraviroc, Fusion Inhibitors, Integrase Inhibitors Deck (9)
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1
Q

The gag gene encodes for proteins that are where in the virion?

A

Within the capsid (just like the gagged prisoners in the center of the ship around the sundial)

2
Q

What proteins does gag encode?

A

It makes p24 and p7.

Think of the sundial having 24 hours 7 days a week.

3
Q

Which HIV protein allows for entry into host cells?

A

gp120 (like the 120 ram)

4
Q

What drug inhibits the entry of HIV virions?

A

Maraviroc (like the MARe rearing up in front of the poor defenseless squire)

5
Q

Enfuvirtide inhibits a protein created by which gene?

A

Env (specifically, it inhibits the gp41 fusion protein)

6
Q

Env genes have to be processed in ____________.

A

the endoplasmic reticulum

Think of the ER waves beneath the invading boat.

7
Q

The pol gene encodes for ________________.

A

new enzymes: reverse transcriptase, protease, and integrase

Think of Paul the blacksmith making new enzymes.

8
Q

Which protein does raltegravir inhibit?

A

It inhibits inTEGrase.

Think of the key deflector.

9
Q

Integrase inhibitors can cause _______________.

A

myopathy (represented by the CK bucket of chicken)

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