Sketchy - Tetracyclines Flashcards Preview

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Flashcards in Sketchy - Tetracyclines Deck (12):
1

MOA: Tetracyclines

Bind reversibly to the 30S ribosomal subunit and interfere with bacterial protein synthesis;
Bacteriostatic;
Broad spectrum

2

Class: Minocycline

Tetracycline

3

What is first line treatment for rickettsial species?

Tetracyclines namely Doxycycline
Francisella --> tuleremia
Borrelia --> Lyme disease
Erlichia --> Erlichiosis
Rickettsia --> RMSF

4

What is first line treatment for zoonoses such as Brucellosis, Yersinia and Coxiella?

Doxycycline
Coxiella - Q fever, endocarditis

5

1 week treatment with what is effective for Chlamydia urethritis and cervicitis?

Doxycycline

When PID is suspected, Doxy os a cephalosporin are good

6

CAP due to atypical bugs such as chlamydia and mycoplasma are effectively treated with:

Doxycycline

7

Tetracycline absorption is decreased with calcium, iron and magnesium because

They chelate them (or any multivalent cation)

8

Why are tetracyclines not recommended for children under 8?

They chelate calcium and discolor developing teeth;
Same goes for fetal teeth and bone - do not administer tetracyclines to pregnant women

9

Side effects: Tetracyclines

Nausea
Vomiting
Diarrhea;
Skin photosensitivity

10

Administration of expired tetracylcines can cause

Fanconi syndrome, a type 2 renal tubular acidosis

11

What are common methods of resisting tetracyclines?

Efflux pumps;
Altered ribosomes

12

Do tetracyclines require dose adjustment for renal failure patients?

No, they are eliminated fecally