Flashcards in Sketchy - Tetracyclines Deck (12):
Bind reversibly to the 30S ribosomal subunit and interfere with bacterial protein synthesis;
What is first line treatment for rickettsial species?
Tetracyclines namely Doxycycline
Francisella --> tuleremia
Borrelia --> Lyme disease
Erlichia --> Erlichiosis
Rickettsia --> RMSF
What is first line treatment for zoonoses such as Brucellosis, Yersinia and Coxiella?
Coxiella - Q fever, endocarditis
1 week treatment with what is effective for Chlamydia urethritis and cervicitis?
When PID is suspected, Doxy os a cephalosporin are good
CAP due to atypical bugs such as chlamydia and mycoplasma are effectively treated with:
Tetracycline absorption is decreased with calcium, iron and magnesium because
They chelate them (or any multivalent cation)
Why are tetracyclines not recommended for children under 8?
They chelate calcium and discolor developing teeth;
Same goes for fetal teeth and bone - do not administer tetracyclines to pregnant women
Side effects: Tetracyclines
Administration of expired tetracylcines can cause
Fanconi syndrome, a type 2 renal tubular acidosis
What are common methods of resisting tetracyclines?