Sketchy - Vancomycin Flashcards Preview

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Flashcards in Sketchy - Vancomycin Deck (12):
1

Spectrum: Vancomycin

Gram pos is Staph/Strep;
Enterococcus species

2

What is one of the most important indications for Vancomycin?

Blood stream infections of MRSA; HAP due to MRSA

3

Is Vancomycin bateriocidal or bacteriostatic?

Bacteriocidal

4

Do beta-lactamases affect Vancomycin?

No

5

What is the first line treatment for MRSA Osteomyelitis?

Vancomycin, because it penetrates well into bone

6

What is a good option for treating Staph epidermidis, responsible for biolfims on heart valves and IV lines?

Vancomycin

7

What is the first line treatment for endocarditis?

Vancomycin

8

What confers resistance to Vancomycin?

Altered peptidoglycan structure D-ala-D-lac

9

What is the first-line treatment for C. diff infection?

Metronidazole

Use oral vancomycin next if first-line therapy is ineffective (take a van to the met)

10

Adverse effects: Vancomycin

Red man syndrome - histamine release
Prevent by prolonging infusion or using antihistamines;
Thrombophlebitis at the injection site;
Ototoxicity and Nephrotoxicity when used with other ototixic or nephrotoxic drugs;
DRESS syndrome

11

What is DRESS syndrome?

Drug reaction with eosinophilia and systemic symptoms;
Can occur with Vancomycin when administered with allopurinol, anticonvulsants or sulfonamides;
2-8 weeks post-admin reaction

12

MOA: Vancomycin

Binds directly to the D-ala-D-ala structure of bacterial cell wall