Flashcards in Skin pathophysiology: eczema, dermatitis, psoriasis 1 Deck (7)
What is the definition of atopic?
Related to allergic response
Which gene is important for encoding epidermal structural proteins?
Filaggrin gene - in chromosome 1
What is the role of filaggrin gene?
Produces protein that binds to keratin fibres in the epidermis of skin
Keratin molecules glue barrier together to form tight sheet
Chronic, relapsing inflammation of the skin
Broad term for eczema?
Dermatitis (umbrella term)
Name the TWO hypotheses associated with development of atopic dermatitis
1. Immunological hypothesis
2. Skin barrier hypothesis