Flashcards in SLE Deck (17):
what antibodies are highly specific for SLE?
Anti smith and anti double stranded DNA antibodies
more common in male or female?
which ethnicities are predisposed to SLE
Asian, African, Hispanic
how do we diagnose SLE
11 criteria for SLE- 4 out 11 indicates SLE. These 4 symptoms do not need to occur simultaneously to each other
- Think SOAP BRAIN MD
O- oral ulcers
B- Blood disorders
R- renal involvement
A-anti nuclear antibodies
I-immunological- anti smith, anti ds dna antibodies
N- neurological involvement
M- malar rash
D- discoid rash
what are the neurological manifestations of SLE?
seizures or psychosis
what do we mean by serositis
pleuritis or pericarditis
what does SLE stand for?
Systemic lupus erythematosus
what is the pathophysiology of SLE?
B cells inappropriately produce autoantibodies against a variety of auto antigens such as nuclear antibodies. These autoantibodies attack a number of tissues/organs causing damage via immune complex deposition, complement activation etc.
what auto antibodies are associated with SLE
Anti Sm (smith), anti Ds DNA, anti nuclear (ANA), anti Ro, anti La antibodies. The main ones are ANAs and anti DS DNA
what other conditions is SLE associated with?
Sjogren's syndrome, autoimmune thyroid disease and antiphospholipid syndrome
What tests can we order to monitor SLE?
1. anti ds DNA antibody titres
2. complement levels (reduced C3, C4 indicate consumption)
3. ESR, CRP (ESR high but CRP normal)
what are some signs of acute SLE?
haemolytic anaemia, nephritis, pericarditis, CNS disease
what are some musculoskeletal signs of SLE?
symmetrical small joint arthralgia
what might you see on FBE?
anaemia usually anaemia of chronic disease or warm autoimmune anaemia
what type of glomerulonephritis is associated with SLE? what might you see histologically?
proliferative GM. you would see increased mesangial matrix and hypercellularity
is lupus associated with synovitis- like RA?
no not usually