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Flashcards in SLE Deck (17):
1

what antibodies are highly specific for SLE?

Anti smith and anti double stranded DNA antibodies

2

more common in male or female?

female

3

which ethnicities are predisposed to SLE

Asian, African, Hispanic

4

how do we diagnose SLE

11 criteria for SLE- 4 out 11 indicates SLE. These 4 symptoms do not need to occur simultaneously to each other
- Think SOAP BRAIN MD
S- serositis
O- oral ulcers
A- arthritis
P- photosensitivity

B- Blood disorders
R- renal involvement
A-anti nuclear antibodies
I-immunological- anti smith, anti ds dna antibodies
N- neurological involvement

M- malar rash
D- discoid rash

5

what are the neurological manifestations of SLE?

seizures or psychosis

6

what do we mean by serositis

pleuritis or pericarditis

7

what does SLE stand for?

Systemic lupus erythematosus

8

what is the pathophysiology of SLE?

B cells inappropriately produce autoantibodies against a variety of auto antigens such as nuclear antibodies. These autoantibodies attack a number of tissues/organs causing damage via immune complex deposition, complement activation etc.

9

what auto antibodies are associated with SLE

Anti Sm (smith), anti Ds DNA, anti nuclear (ANA), anti Ro, anti La antibodies. The main ones are ANAs and anti DS DNA

10

what other conditions is SLE associated with?

Sjogren's syndrome, autoimmune thyroid disease and antiphospholipid syndrome

11

What tests can we order to monitor SLE?

1. anti ds DNA antibody titres
2. complement levels (reduced C3, C4 indicate consumption)
3. ESR, CRP (ESR high but CRP normal)

12

what are some signs of acute SLE?

haemolytic anaemia, nephritis, pericarditis, CNS disease

13

what are some musculoskeletal signs of SLE?

symmetrical small joint arthralgia

14

what might you see on FBE?

anaemia usually anaemia of chronic disease or warm autoimmune anaemia

15

what type of glomerulonephritis is associated with SLE? what might you see histologically?

proliferative GM. you would see increased mesangial matrix and hypercellularity

16

is lupus associated with synovitis- like RA?

no not usually

17

describe some symptoms of lupus nephritis?

• AKI
• Proteinuria
• Nephrotic syndrome
• Haematuria
• Hyperkalemia
Hypertension